Scholarlink

Objectives <p>Cervical squamous cell carcinoma (CESC) is the most common pathological type of cervical cancer. This study aimed to investigate the clinical relevance and functional role of miR-127-5p in CESC.</p> Method <p>This study analyzed <i>miR-127-5p</i> expression in tumor and paired adjacent tissues from 134 CESC patients, and evaluated its association with clinicopathological features and prognosis using Kaplan-Meier and Cox regression analyses. The effects of <i>miR-127-5p</i> on cell functions were assessed by CCK-8 and Transwell assays, and its interaction with SNX10 was investigated using dual-luciferase and rescue experiments.</p> Results <p>In CESC tissues, <i>miR-127-5p</i> was significantly downregulated and this downregulation correlated with advanced FIGO stage and positive lymph node metastasis. Kaplan-Meier analysis showed that patients in the low <i>miR-127-5p</i> expression group had a lower 5-year survival rate. Cox regression analysis indicated that <i>miR-127-5p</i> is an independent factor affecting patient prognosis. Overexpression of <i>miR-127-5p</i> suppressed CESC cell proliferation, migration, and invasion by directly targeting the 3’UTR of SNX10, with rescue experiments identifying SNX10 as a key functional mediator that regulates EMT and autophagy-related pathways.</p> Conclusions <p><i>miR-127-5p</i> is lowly expressed in CESC and can serve as a potential prognostic biomarker. <i>MiR-127-5p</i> may inhibit the malignant behavior of CESC cells by targeting SNX10.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The prognostic value of miR-127-5p in cervical squamous cell carcinoma and its role in suppressing malignant behavior of cancer cells via SNX10 inhibition

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月28日

查看全文
  • Jing Zhu,
  • Yingying Huang,
  • Donglian Lan,
  • Sanying Guo

摘要

Objectives

Cervical squamous cell carcinoma (CESC) is the most common pathological type of cervical cancer. This study aimed to investigate the clinical relevance and functional role of miR-127-5p in CESC.

Method

This study analyzed miR-127-5p expression in tumor and paired adjacent tissues from 134 CESC patients, and evaluated its association with clinicopathological features and prognosis using Kaplan-Meier and Cox regression analyses. The effects of miR-127-5p on cell functions were assessed by CCK-8 and Transwell assays, and its interaction with SNX10 was investigated using dual-luciferase and rescue experiments.

Results

In CESC tissues, miR-127-5p was significantly downregulated and this downregulation correlated with advanced FIGO stage and positive lymph node metastasis. Kaplan-Meier analysis showed that patients in the low miR-127-5p expression group had a lower 5-year survival rate. Cox regression analysis indicated that miR-127-5p is an independent factor affecting patient prognosis. Overexpression of miR-127-5p suppressed CESC cell proliferation, migration, and invasion by directly targeting the 3’UTR of SNX10, with rescue experiments identifying SNX10 as a key functional mediator that regulates EMT and autophagy-related pathways.

Conclusions

miR-127-5p is lowly expressed in CESC and can serve as a potential prognostic biomarker. MiR-127-5p may inhibit the malignant behavior of CESC cells by targeting SNX10.