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Background <p>Malignant carotid body tumor (CBT), a type of carotid body paraganglioma (PGL), is defined by the presence of distant metastasis; histology alone cannot reliably distinguish benign from malignant CBT.</p> Case summary <p>We present a 70-year-old female patient who had been suspected of having CBT for more than 10 years without specific treatment, and complained of abdominal pain for 6 months. Contrast-enhanced MRI and CT revealed a T11 vertebral lesion, followed by percutaneous biopsy of the lesion, which showed atypical cell nests. Immunohistochemical staining was positive for CD56, CgA, Syn and S-100, and negative for cytokeratin. A diagnosis of metastatic PGL consistent with malignant CBT was established. The patient received palliative radiotherapy to the T11 vertebra (20&#xa0;Gy/5 fractions), which was well tolerated without obvious radiation-related adverse reactions. At the 12-month follow-up, the patient remained alive.</p> Conclusion <p>In this case, a highly suggestive diagnosis of PGL (malignant CBT) with bone metastasis was made based on imaging features, T11 vertebral biopsy, and immunohistochemical results. It provides a reference for radiotherapy in similar clinical settings. For unresectable thoracic vertebral metastases, palliative radiotherapy (20&#xa0;Gy/5 fractions) can be considered after clinical evaluation.</p>

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A case report of carotid body tumor with rare thoracic vertebral metastasis and literature review

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月20日

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  • Fei Li,
  • Jie Yang,
  • Juan Zhang,
  • Mengfan Zhao,
  • Shuai Qie,
  • Shasha Zang

摘要

Background

Malignant carotid body tumor (CBT), a type of carotid body paraganglioma (PGL), is defined by the presence of distant metastasis; histology alone cannot reliably distinguish benign from malignant CBT.

Case summary

We present a 70-year-old female patient who had been suspected of having CBT for more than 10 years without specific treatment, and complained of abdominal pain for 6 months. Contrast-enhanced MRI and CT revealed a T11 vertebral lesion, followed by percutaneous biopsy of the lesion, which showed atypical cell nests. Immunohistochemical staining was positive for CD56, CgA, Syn and S-100, and negative for cytokeratin. A diagnosis of metastatic PGL consistent with malignant CBT was established. The patient received palliative radiotherapy to the T11 vertebra (20 Gy/5 fractions), which was well tolerated without obvious radiation-related adverse reactions. At the 12-month follow-up, the patient remained alive.

Conclusion

In this case, a highly suggestive diagnosis of PGL (malignant CBT) with bone metastasis was made based on imaging features, T11 vertebral biopsy, and immunohistochemical results. It provides a reference for radiotherapy in similar clinical settings. For unresectable thoracic vertebral metastases, palliative radiotherapy (20 Gy/5 fractions) can be considered after clinical evaluation.