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Introduction <p>Colorectal cancer (CRC), originating in the colon or rectum, is a leading cause of mortality worldwide. Patient survival is influenced by multiple factors, including access to healthcare, early diagnosis, and treatment.</p> Objective <p>This study evaluates the prognostic influence of clinicopathological and laboratory factors on colorectal cancer survival.</p> Methods <p>A cohort study was conducted at an institutional level retrospective cohort, including 464 participants who began follow-up between July 1, 2018, and June 30, 2023. Data were entered into Epidata V4.2 and analyzed using STATA V14. Cox regression models were applied to identify factors associated with mortality. Variables with a P-value &lt; 0.25 in the bivariable analysis were included in the multivariable Cox regression model, with statistical significance set at <i>P</i> ≤ 0.05.</p> Results <p>Several factors significantly impacted survival, including rectal cancer (AHR = 1.88, 95% CI: 1.27–2.78), colorectal cancer (AHR = 2.29, 95% CI: 1.56–3.36), baseline ALP levels ≥ 127 IU/L (AHR = 1.56, 95% CI: 1.15–2.09), poor WHO/ECOG performance status (AHR = 2.41, 95% CI: 1.74–3.34), and late-stage cancer (AHR = 3.46, 95% CI: 2.14–5.59).</p> Conclusion and Recommendations <p>Key determinants of CRC survival include ALP levels, tumor stage, performance status, and tumor location. Enhancing diagnostic capabilities and ensuring continuous patient monitoring may improve outcomes.</p>

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Prognostic influence of clinicopathological and laboratory factors on colorectal cancer survival in Amhara region oncology centers, retrospective cohort study, Ethiopia, 2024

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月19日

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  • Getachew Tesfaw Walle,
  • Seteamlak Adane Masresha,
  • Tegene Atamenta kitaw,
  • Betelhem Walelgn Dagnew,
  • Biruk Beletew Abate,
  • Molla Azmeraw

摘要

Introduction

Colorectal cancer (CRC), originating in the colon or rectum, is a leading cause of mortality worldwide. Patient survival is influenced by multiple factors, including access to healthcare, early diagnosis, and treatment.

Objective

This study evaluates the prognostic influence of clinicopathological and laboratory factors on colorectal cancer survival.

Methods

A cohort study was conducted at an institutional level retrospective cohort, including 464 participants who began follow-up between July 1, 2018, and June 30, 2023. Data were entered into Epidata V4.2 and analyzed using STATA V14. Cox regression models were applied to identify factors associated with mortality. Variables with a P-value < 0.25 in the bivariable analysis were included in the multivariable Cox regression model, with statistical significance set at P ≤ 0.05.

Results

Several factors significantly impacted survival, including rectal cancer (AHR = 1.88, 95% CI: 1.27–2.78), colorectal cancer (AHR = 2.29, 95% CI: 1.56–3.36), baseline ALP levels ≥ 127 IU/L (AHR = 1.56, 95% CI: 1.15–2.09), poor WHO/ECOG performance status (AHR = 2.41, 95% CI: 1.74–3.34), and late-stage cancer (AHR = 3.46, 95% CI: 2.14–5.59).

Conclusion and Recommendations

Key determinants of CRC survival include ALP levels, tumor stage, performance status, and tumor location. Enhancing diagnostic capabilities and ensuring continuous patient monitoring may improve outcomes.