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<p>BET1 encodes a Golgi-associated membrane protein involved in vesicular transport from the endoplasmic reticulum (ER) to the Golgi apparatus. While the role of BET1 in cancer development remains poorly understood, its function in glioblastoma multiforme (GBM) has not been systematically investigated. In this study, we found that 15 out of 33 cancer types showed significant differential BET1 expression between tumor and normal tissues. Furthermore, survival analysis identified BET1 as an independent prognostic factor in GBM. Additional analyses revealed correlations between BET1 expression and the infiltration of immune cells, such as Tregs and CD4 + T cells, in GBM. Moreover, BET1 knockdown in glioblastoma cells reduced their proliferation and migration capacities. This study provides a comprehensive analysis of BET1, thereby advancing our understanding of its oncogenic potential in GBM.</p>

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BET1 serves as a prognostic indicator and promotes cancer proliferation in glioblastoma multiforme

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月29日

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  • Yu Li,
  • Changmeng Wu,
  • Yuhao Xia,
  • Li Lin,
  • Juan He,
  • Linlin Xu,
  • Yong Xia,
  • Ling Ji

摘要

BET1 encodes a Golgi-associated membrane protein involved in vesicular transport from the endoplasmic reticulum (ER) to the Golgi apparatus. While the role of BET1 in cancer development remains poorly understood, its function in glioblastoma multiforme (GBM) has not been systematically investigated. In this study, we found that 15 out of 33 cancer types showed significant differential BET1 expression between tumor and normal tissues. Furthermore, survival analysis identified BET1 as an independent prognostic factor in GBM. Additional analyses revealed correlations between BET1 expression and the infiltration of immune cells, such as Tregs and CD4 + T cells, in GBM. Moreover, BET1 knockdown in glioblastoma cells reduced their proliferation and migration capacities. This study provides a comprehensive analysis of BET1, thereby advancing our understanding of its oncogenic potential in GBM.