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Purpose <p>Acetylation, a critical epigenetic modification, plays a central role in regulating gene expression, chromatin accessibility, protein function, and tumor progression. In lung cancer, aberrant acetylation has been implicated in processes such as metastasis, immune evasion, and therapy resistance. Despite growing scientific interest, a comprehensive bibliometric evaluation of research on acetylation in lung cancer has not yet been conducted. This study aims to systematically explore global research trends, collaboration networks, influential contributors, and emerging thematic hotspots in acetylation-related lung cancer research over the past 25 years, offering strategic insight into both foundational mechanisms and translational opportunities.</p> Methods <p>A total of 917 English-language publications from 2000 to 2025 were retrieved from the Web of Science Core Collection (WoSCC). Bibliometric analyses were performed using VOSviewer, CiteSpace, Scimago Graphica, and Charticulator. Key metrics such as publication growth, country and institutional contributions, author impact, keyword co-occurrence, and citation bursts were examined to map the knowledge structure and research frontiers.</p> Results <p>The annual number of publications and citations has increased significantly, particularly after 2015. China and the United States are the leading contributors, with Chinese institutions dominating in volume and U.S. scholars exhibiting greater citation influence. Major research clusters focus on histone deacetylases, EMT, immune regulation, and non-apoptotic cell death pathways including ferroptosis and autophagy. Recent studies emphasize the potential of combining acetylation-targeting agents with immunotherapies and nanomedicine to overcome resistance and enhance therapeutic efficacy.</p> Conclusion <p>Acetylation has become a pivotal regulatory mechanism and therapeutic target in lung cancer research. This bibliometric study reveals evolving hotspots and interdisciplinary linkages, highlighting the need for deeper mechanistic studies, international collaboration, and the integration of epigenetic strategies into precision oncology. The findings provide a valuable reference for future basic and translational research in lung cancer epigenetics.</p>

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A bibliometric and visualization analysis of global trends and emerging themes in acetylation research for lung cancer

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月25日

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  • Jinman Li,
  • Qiao Fan

摘要

Purpose

Acetylation, a critical epigenetic modification, plays a central role in regulating gene expression, chromatin accessibility, protein function, and tumor progression. In lung cancer, aberrant acetylation has been implicated in processes such as metastasis, immune evasion, and therapy resistance. Despite growing scientific interest, a comprehensive bibliometric evaluation of research on acetylation in lung cancer has not yet been conducted. This study aims to systematically explore global research trends, collaboration networks, influential contributors, and emerging thematic hotspots in acetylation-related lung cancer research over the past 25 years, offering strategic insight into both foundational mechanisms and translational opportunities.

Methods

A total of 917 English-language publications from 2000 to 2025 were retrieved from the Web of Science Core Collection (WoSCC). Bibliometric analyses were performed using VOSviewer, CiteSpace, Scimago Graphica, and Charticulator. Key metrics such as publication growth, country and institutional contributions, author impact, keyword co-occurrence, and citation bursts were examined to map the knowledge structure and research frontiers.

Results

The annual number of publications and citations has increased significantly, particularly after 2015. China and the United States are the leading contributors, with Chinese institutions dominating in volume and U.S. scholars exhibiting greater citation influence. Major research clusters focus on histone deacetylases, EMT, immune regulation, and non-apoptotic cell death pathways including ferroptosis and autophagy. Recent studies emphasize the potential of combining acetylation-targeting agents with immunotherapies and nanomedicine to overcome resistance and enhance therapeutic efficacy.

Conclusion

Acetylation has become a pivotal regulatory mechanism and therapeutic target in lung cancer research. This bibliometric study reveals evolving hotspots and interdisciplinary linkages, highlighting the need for deeper mechanistic studies, international collaboration, and the integration of epigenetic strategies into precision oncology. The findings provide a valuable reference for future basic and translational research in lung cancer epigenetics.