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<p>Lung cancer continues to present a substantial global health and economic challenge, with consistently high rates of incidence and mortality. While there have been significant strides in precision diagnostics and treatment methods that have contributed to a reduction in mortality over previous years, progress has plateaued recently, largely due to complications such as side effects and resistance to therapies. Emerging research indicates that interleukin-17 (IL-17), a cytokine with pro-inflammatory properties, plays a critical role in various stages of lung cancer, including initiation, growth, invasion, metastasis, angiogenesis, lymphangiogenesis, and treatment resistance. This positions IL-17 as both a crucial regulator and a valuable prognostic marker for the disease’s progression. This review aims to provide an overview of the most recent developments in IL-17 research as it relates to lung cancer, offering a theoretical framework for its potential as a therapeutic target in both the prevention and treatment of lung cancer.</p>

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Regulatory role of IL-17-mediated inflammatory pathways in lung cancer initiation and progression

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月26日

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  • Xinjia Xu,
  • Xinan Lu,
  • Wei Wu,
  • Xinyi Chen,
  • Aijun Zhang

摘要

Lung cancer continues to present a substantial global health and economic challenge, with consistently high rates of incidence and mortality. While there have been significant strides in precision diagnostics and treatment methods that have contributed to a reduction in mortality over previous years, progress has plateaued recently, largely due to complications such as side effects and resistance to therapies. Emerging research indicates that interleukin-17 (IL-17), a cytokine with pro-inflammatory properties, plays a critical role in various stages of lung cancer, including initiation, growth, invasion, metastasis, angiogenesis, lymphangiogenesis, and treatment resistance. This positions IL-17 as both a crucial regulator and a valuable prognostic marker for the disease’s progression. This review aims to provide an overview of the most recent developments in IL-17 research as it relates to lung cancer, offering a theoretical framework for its potential as a therapeutic target in both the prevention and treatment of lung cancer.