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<p>Colorectal cancer is a major cause of morbidity and mortality worldwide. Early detection and diagnosis are critical for effective treatment, and the identification of prognostic biomarkers is essential for predicting patient outcomes. Recent advances in machine learning have enabled researchers to analyze large datasets of genomics and clinical data to identify novel biomarkers and therapeutic targets. In this study, we aim to examine the gene network and prognostic biomarkers involved in the onset of colorectal cancer in stool samples using machine learning. We will analyze data from a cohort of patients with colorectal cancer and healthy controls, including genomic data, clinical data, and stool samples. We will use a variety of machine learning techniques, including deep learning and network analysis, to identify patterns and relationships between genes, biomarkers, and clinical outcomes. Our preliminary results suggest that machine learning can be used to identify novel biomarkers and gene networks associated with the onset of colorectal cancer in stool samples. We have identified several candidate biomarkers that are significantly associated with disease progression and patient outcomes. These findings have the potential to improve our understanding of the molecular mechanisms underlying colorectal cancer pathogenesis and to identify new targets for therapy. In conclusion, our study demonstrates the feasibility and utility of using machine learning to analyze complex datasets of genomics and clinical data in the context of colorectal cancer. We anticipate that this approach will lead to the development of more accurate prognostic biomarkers and personalized therapies for patients with colorectal cancer.</p>

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Examining the gene network and prognostic biomarkers in the onset of colorectal cancer in stool samples using machine learning

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月16日

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  • Reza Shaghaghi Shahr,
  • Mohaddese Sadat Mahmoudi,
  • Nasim Amirnia,
  • Fatemeh Karimpour,
  • Atefeh Noori,
  • Amir Khanmirzaei,
  • Tabasom Hassania,
  • Bahar Karimikhoshnoudian,
  • Paniz Nasiri,
  • Amir-Reza Javanmard

摘要

Colorectal cancer is a major cause of morbidity and mortality worldwide. Early detection and diagnosis are critical for effective treatment, and the identification of prognostic biomarkers is essential for predicting patient outcomes. Recent advances in machine learning have enabled researchers to analyze large datasets of genomics and clinical data to identify novel biomarkers and therapeutic targets. In this study, we aim to examine the gene network and prognostic biomarkers involved in the onset of colorectal cancer in stool samples using machine learning. We will analyze data from a cohort of patients with colorectal cancer and healthy controls, including genomic data, clinical data, and stool samples. We will use a variety of machine learning techniques, including deep learning and network analysis, to identify patterns and relationships between genes, biomarkers, and clinical outcomes. Our preliminary results suggest that machine learning can be used to identify novel biomarkers and gene networks associated with the onset of colorectal cancer in stool samples. We have identified several candidate biomarkers that are significantly associated with disease progression and patient outcomes. These findings have the potential to improve our understanding of the molecular mechanisms underlying colorectal cancer pathogenesis and to identify new targets for therapy. In conclusion, our study demonstrates the feasibility and utility of using machine learning to analyze complex datasets of genomics and clinical data in the context of colorectal cancer. We anticipate that this approach will lead to the development of more accurate prognostic biomarkers and personalized therapies for patients with colorectal cancer.