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<p>The structural coupling between organelles is considered central to regulating cellular behavior. While each organelle performs specific functions, contact or structural coupling between them enables highly coordinated functionality. Mitochondria and the endoplasmic reticulum (ER) are vital organelles in eukaryotic cells, serving as the centers of oxidative metabolism and protein synthesis, respectively. Their homeostatic and coordinated interactions are essential for maintaining cellular activity. This review outlines the structure, function, research methodologies, and relationship with tumorigenesis of the mitochondria-associated membranes (MAMs). And discusses the potential of MAMs as therapeutic targets for cancer therapy and drug development.</p>

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The role of mitochondria-associated membranes in tumorigenesis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月26日

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  • Yaqin Zhu,
  • Guoyi Tang,
  • Muya Tang,
  • Baozhen Zhou,
  • Jing Xu,
  • Xiaoli Ma,
  • Ziyu Li,
  • Guichun Liu,
  • Yu Han

摘要

The structural coupling between organelles is considered central to regulating cellular behavior. While each organelle performs specific functions, contact or structural coupling between them enables highly coordinated functionality. Mitochondria and the endoplasmic reticulum (ER) are vital organelles in eukaryotic cells, serving as the centers of oxidative metabolism and protein synthesis, respectively. Their homeostatic and coordinated interactions are essential for maintaining cellular activity. This review outlines the structure, function, research methodologies, and relationship with tumorigenesis of the mitochondria-associated membranes (MAMs). And discusses the potential of MAMs as therapeutic targets for cancer therapy and drug development.