Scholarlink

<p>Members of the XRCC family have been reported to be closely associated with the initiation and progression of certain human cancers. The purpose of this study is to comprehensively analyze the role of the XRCC family in pan-cancer. In this study, we primarily utilized data downloaded from The Cancer Genome Atlas (TCGA). We investigated the prognostic significance of the XRCC family and its association with tumor mutation burden (TMB), microsatellite instability (MSI), drug sensitivity, and immunotherapy in several human cancers. The findings indicated that the expression of the XRCC family was primarily upregulated in most tumors. The XRCC family was associated with the prognosis of cancer patients. Then, XRCC family genes showed a significant association with tumor immune microenvironment and tumor cell stemness. Finally, we also analyzed the potential role of the XRCC family in cancer therapy. This study conducts a comprehensive analysis of the role of the XRCC family in pan-cancer, which contributes to providing a potential direction for cancer diagnosis and treatment. </p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Multi-omics analysis reveals the role of the XRCC gene family in diagnosis, prognosis, and immunity in pan-cancer

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月4日

查看全文
  • Jianhui Chen,
  • Hantian Guan,
  • Yitian Bai,
  • Yangyang Guo,
  • Xuejian Wang,
  • Dandan Wang

摘要

Members of the XRCC family have been reported to be closely associated with the initiation and progression of certain human cancers. The purpose of this study is to comprehensively analyze the role of the XRCC family in pan-cancer. In this study, we primarily utilized data downloaded from The Cancer Genome Atlas (TCGA). We investigated the prognostic significance of the XRCC family and its association with tumor mutation burden (TMB), microsatellite instability (MSI), drug sensitivity, and immunotherapy in several human cancers. The findings indicated that the expression of the XRCC family was primarily upregulated in most tumors. The XRCC family was associated with the prognosis of cancer patients. Then, XRCC family genes showed a significant association with tumor immune microenvironment and tumor cell stemness. Finally, we also analyzed the potential role of the XRCC family in cancer therapy. This study conducts a comprehensive analysis of the role of the XRCC family in pan-cancer, which contributes to providing a potential direction for cancer diagnosis and treatment.