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<p>Esophageal cancer (EC) is a global health challenge with limited treatment and low efficacy. The role of vascular endothelial growth factor receptor 2 (VEGFR2) in EC has attracted significant attention. In this study, we found that anlotinib, an oral VEGFR2 inhibitor, exhibited a strong inhibitory effect on EC in vitro and in vivo. Moreover, VEGFR2 expression was positively correlated with infiltration levels of macrophages and dendritic cells (DCs) via comprehensive analysis and molecular experiment. Together, we evaluated the correlations between VEGFR2 expression and immune infiltration and explored the role of anlotinib on EC, providing a potential strategy for the intervention of EC.</p>

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Anlotinib inhibits esophageal cancer malignancy by ameliorating the immune microenvironment

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月23日

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  • Zhao Minghong,
  • Yuan Lin,
  • Huang Xi,
  • Xia Chunjun,
  • Sun Xiaoyi,
  • Meng Lingyun,
  • Yang Junchang,
  • Yan Wenyue

摘要

Esophageal cancer (EC) is a global health challenge with limited treatment and low efficacy. The role of vascular endothelial growth factor receptor 2 (VEGFR2) in EC has attracted significant attention. In this study, we found that anlotinib, an oral VEGFR2 inhibitor, exhibited a strong inhibitory effect on EC in vitro and in vivo. Moreover, VEGFR2 expression was positively correlated with infiltration levels of macrophages and dendritic cells (DCs) via comprehensive analysis and molecular experiment. Together, we evaluated the correlations between VEGFR2 expression and immune infiltration and explored the role of anlotinib on EC, providing a potential strategy for the intervention of EC.