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Background <p>Lung cancer is one of the malignant tumors with high morbidity and mortality worldwide. Nuclear factor E2-ralated factor 2 (Nrf2), a critical antioxidant transcription factor, has been identified to play a significant role in the pathogenesis, progression and chemoresistance of lung cancer through its dysregulated activation. The present investigation sought to enhance our understanding of the global research landscape concerning Nrf2 in lung cancer by employing a bibliometric methodology.</p> Methods <p>The present study retrieved relevant articles and reviews concerning Nrf2 in lung cancer from the Web of Science Core Collection and Scopus databases. A comprehensive bibliometric analysis was conducted utilizing a suite of tools including Microsoft Excel, Python, CiteSpace, VOSviewer, R (bibliometrix), and Charticulator to evaluate various aspects such as publication productivity, contributing nations, affiliated institutions, prominent authors, influential journals, co-cited references, and thematic keywords.</p> Results <p>The study encompassed 1931 publications, showing a marked rise in citations from 2002 to 2025. China dominated the publication landscape, with several leading institutions contributing. Professors Masayuki Yamamoto and Shyam Biswal were identified as key contributors. <i>Cancer Research</i> was the most prolific journal. Nrf2 played a central role in lung cancer research, with research hotspots evolving from basic studies to clinical treatment strategies and increasing interest in specific lung cancer subtypes, reflecting the multidimensional and interdisciplinary development of the field.</p> Conclusion <p>Research on Nrf2 in lung cancer has shifted from basic cell typing to studies of oxidation and programmed cell death, and it is time to dissect upstream regulators and create targeted Nrf2 modulators for personalized treatment.</p>

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Nrf2 functions as a biomarker and therapeutic target in lung cancer based on bibliometric analysis and molecular mechanisms

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月25日

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  • Haixia Fan,
  • Shudan Deng,
  • Limantian Wang,
  • Lu Zhai,
  • Yan Li,
  • Huiyan Niu,
  • Bomeng Zhao,
  • Xiaoling Gao

摘要

Background

Lung cancer is one of the malignant tumors with high morbidity and mortality worldwide. Nuclear factor E2-ralated factor 2 (Nrf2), a critical antioxidant transcription factor, has been identified to play a significant role in the pathogenesis, progression and chemoresistance of lung cancer through its dysregulated activation. The present investigation sought to enhance our understanding of the global research landscape concerning Nrf2 in lung cancer by employing a bibliometric methodology.

Methods

The present study retrieved relevant articles and reviews concerning Nrf2 in lung cancer from the Web of Science Core Collection and Scopus databases. A comprehensive bibliometric analysis was conducted utilizing a suite of tools including Microsoft Excel, Python, CiteSpace, VOSviewer, R (bibliometrix), and Charticulator to evaluate various aspects such as publication productivity, contributing nations, affiliated institutions, prominent authors, influential journals, co-cited references, and thematic keywords.

Results

The study encompassed 1931 publications, showing a marked rise in citations from 2002 to 2025. China dominated the publication landscape, with several leading institutions contributing. Professors Masayuki Yamamoto and Shyam Biswal were identified as key contributors. Cancer Research was the most prolific journal. Nrf2 played a central role in lung cancer research, with research hotspots evolving from basic studies to clinical treatment strategies and increasing interest in specific lung cancer subtypes, reflecting the multidimensional and interdisciplinary development of the field.

Conclusion

Research on Nrf2 in lung cancer has shifted from basic cell typing to studies of oxidation and programmed cell death, and it is time to dissect upstream regulators and create targeted Nrf2 modulators for personalized treatment.