Scholarlink

Background <p>Cancer-associated fibroblasts (CAFs) are pivotal stromal components in the tumor microenvironment (TME) of hepatocellular carcinoma (HCC), influencing tumor progression, metastasis, and immunotherapy resistance. However, a comprehensive bibliometric overview of CAFs in HCC is lacking.</p> Methods <p>A systematic search of the Web of Science Core Collection from January 1, 2004, to June 15, 2025 yielded 646 eligible publications. Bibliometric analysis using VOSviewer and CiteSpace mapped publication trends, international collaboration, institutional contributions, author networks, journal impact, and research hotspots.</p> Results <p>A total of 646 articles were analyzed, spanning 282 journals and 2684 keywords. From 2004 to June 15, 2025, there was a significant increase in publications. China led in publication numbers, followed by the US and Japan. Renowned institutions include Sun Yat Sen University, Fudan University, and Zhejiang University. Notable researchers are Fan Jia, Giannelli Gianluigi, and Zhou Jian. The journal with the highest publication and citation frequency is Cancer Research. The main research focuses are the effects of CAFs on HCC cell proliferation, angiogenesis, invasion, metastasis, immunosuppression, and drug resistance, as well as the mechanisms of CAFs in HCC immunotherapy and the progress in targeted CAF research.</p> Conclusion <p>CAFs research in HCC has transitioned from descriptive studies to precision therapeutic targeting. Future directions involve dissecting CAFs plasticity, leveraging single-cell multiomics, and optimizing combination therapies to overcome TME-mediated resistance.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Hotspots and frontiers of the relationship between hepatocellular carcinoma and cancer-associated fibroblasts: a bibliometric analysis and review

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月19日

查看全文
  • Huixia Zheng,
  • Lingling Ren,
  • Guanglan Chen,
  • Xiangcheng Hu

摘要

Background

Cancer-associated fibroblasts (CAFs) are pivotal stromal components in the tumor microenvironment (TME) of hepatocellular carcinoma (HCC), influencing tumor progression, metastasis, and immunotherapy resistance. However, a comprehensive bibliometric overview of CAFs in HCC is lacking.

Methods

A systematic search of the Web of Science Core Collection from January 1, 2004, to June 15, 2025 yielded 646 eligible publications. Bibliometric analysis using VOSviewer and CiteSpace mapped publication trends, international collaboration, institutional contributions, author networks, journal impact, and research hotspots.

Results

A total of 646 articles were analyzed, spanning 282 journals and 2684 keywords. From 2004 to June 15, 2025, there was a significant increase in publications. China led in publication numbers, followed by the US and Japan. Renowned institutions include Sun Yat Sen University, Fudan University, and Zhejiang University. Notable researchers are Fan Jia, Giannelli Gianluigi, and Zhou Jian. The journal with the highest publication and citation frequency is Cancer Research. The main research focuses are the effects of CAFs on HCC cell proliferation, angiogenesis, invasion, metastasis, immunosuppression, and drug resistance, as well as the mechanisms of CAFs in HCC immunotherapy and the progress in targeted CAF research.

Conclusion

CAFs research in HCC has transitioned from descriptive studies to precision therapeutic targeting. Future directions involve dissecting CAFs plasticity, leveraging single-cell multiomics, and optimizing combination therapies to overcome TME-mediated resistance.