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<p>Glaucoma-associated ocular cancers, including uveal melanoma and retinoblastoma, share overlapping pathological mechanisms that complicate diagnosis and treatment. Conventional imaging techniques, such as optical coherence tomography, often fail to distinguish glaucomatous neurodegeneration from tumour-induced damage, while standard chemotherapy and radiotherapy may exacerbate glaucoma progression. These diagnostic and therapeutic challenges highlight the urgent need for integrated management strategies. Recent advances in nanotechnology offer innovative solutions, with nanotherapeutics enabling targeted drug delivery, enhanced imaging contrast, and combined diagnostic–therapeutic (“theranostic”) capabilities. Various nanoparticle platforms have shown promise in improving ocular drug bioavailability, precision targeting, and real-time disease monitoring. This review synthesizes current progress in nanomedicine for glaucoma-associated cancers, emphasizing multifunctional nanoparticles that concurrently support tumour suppression and neuroprotection. Despite encouraging preclinical findings, significant challenges remain, including limited penetration across ocular barriers, uncertain long-term biocompatibility, and complex regulatory requirements. Continued interdisciplinary research integrating nanotechnology with gene editing and vector-based delivery systems may pave the way for personalized, vision-preserving therapies that redefine the treatment paradigm for glaucoma-associated ocular malignancies.</p>

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Nanotherapeutic potential in glaucoma associated ocular cancers

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月28日

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  • Lidawani Lambuk,
  • Muhammad Zulfiqah Sadikan,
  • Mohd Aizuddin Mohd Lazaldin,
  • Fatmawati Lambuk,
  • Ramlah Kadir,
  • Norzila Ismail,
  • Rohimah Mohamud

摘要

Glaucoma-associated ocular cancers, including uveal melanoma and retinoblastoma, share overlapping pathological mechanisms that complicate diagnosis and treatment. Conventional imaging techniques, such as optical coherence tomography, often fail to distinguish glaucomatous neurodegeneration from tumour-induced damage, while standard chemotherapy and radiotherapy may exacerbate glaucoma progression. These diagnostic and therapeutic challenges highlight the urgent need for integrated management strategies. Recent advances in nanotechnology offer innovative solutions, with nanotherapeutics enabling targeted drug delivery, enhanced imaging contrast, and combined diagnostic–therapeutic (“theranostic”) capabilities. Various nanoparticle platforms have shown promise in improving ocular drug bioavailability, precision targeting, and real-time disease monitoring. This review synthesizes current progress in nanomedicine for glaucoma-associated cancers, emphasizing multifunctional nanoparticles that concurrently support tumour suppression and neuroprotection. Despite encouraging preclinical findings, significant challenges remain, including limited penetration across ocular barriers, uncertain long-term biocompatibility, and complex regulatory requirements. Continued interdisciplinary research integrating nanotechnology with gene editing and vector-based delivery systems may pave the way for personalized, vision-preserving therapies that redefine the treatment paradigm for glaucoma-associated ocular malignancies.