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<p>Ovarian cancer (OC), a common gynecological malignancy, seriously threatens the lives and health of women. Though several serological markers are used for the early diagnosis of OC, most have low specificity and sensitivity. Micro-RNAs (miRNAs), a family of non-coding RNAs that function at the post-transcriptional level, are emerging as specific biomarkers to achieve effective diagnosis and treatment strategies for OC. In this review, we summarize the current investigations on miRNAs in the detection and monitoring of OC and discuss the molecular mechanisms that may provide a reliable detection method for OC at early stages. Thus, miRNAs are promising biomarkers, suggesting their potential as therapeutic targets in OC.&#xa0;</p> Graphical Abstract <p></p>

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Potential function of miRNA as a diagnostic biomarker for human ovarian cancer

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月17日

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  • Furong Liu,
  • Zihao An,
  • Chao Tang,
  • Xiaoliang Han

摘要

Ovarian cancer (OC), a common gynecological malignancy, seriously threatens the lives and health of women. Though several serological markers are used for the early diagnosis of OC, most have low specificity and sensitivity. Micro-RNAs (miRNAs), a family of non-coding RNAs that function at the post-transcriptional level, are emerging as specific biomarkers to achieve effective diagnosis and treatment strategies for OC. In this review, we summarize the current investigations on miRNAs in the detection and monitoring of OC and discuss the molecular mechanisms that may provide a reliable detection method for OC at early stages. Thus, miRNAs are promising biomarkers, suggesting their potential as therapeutic targets in OC. 

Graphical Abstract