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Aims <p>This study aims to investigate the prognostic significance of the combined GNR and GPR in patients with early-stage hepatitis B virus-associated hepatocellular carcinoma (HBV-HCC).</p> Methods <p>Retrospective analysis was performed on clinical data of 145 HBV-infected patients with early-stage HCC (ESHCC) who underwent radiofrequency ablation (RFA) and/or surgical resection. Patients were randomly allocated to training (n = 103) and validation (n = 42) cohorts for further survival analysis and model verification. The area under the receiver operating characteristic curves (ROC) was used for evaluating the diagnostic performance of ERM-model. And at the optimal cutoff, a survival analysis on all patients was conducted. Simultaneously, all patients were divided into different subgroups to evaluating ERM-Model.</p> Results <p>Multivariate Cox analysis identified GNR and GPR as independent risk factors for postoperative intrahepatic recurrence (IHR). The combined biomarkers panel demonstrated superior diagnostic accuracy (AUC = 0.812) compared to AFP (AUC = 0.773). Survival analysis showed a significantly higher 2-year cumulative non-IHR rate in the low-risk group (logit(P) &lt; 0.398) verus the high-risk group (logit(P) ≥ 0.398, p &lt; 0.001). Subgroup analysis of all patients that ERM-model showed differencesin HCC stage stratification, with higher diagnostic accuracy for BCLC stage A cases compared to BCLC stage 0 cases.</p> Conclusions <p>GNR and GPR are valuable predictors of IHR in ESHCC. Clinicians can leverage this dual-marker model to assess risk and tailor personalized follow-up strategies.</p>

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A prognostic model based on gamma-glutamyl transpeptidase-derived neutrophil-platelet for predicting intrahepatic recurrence in hepatocellular carcinoma

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月15日

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  • Zhixiao Huo,
  • Lihua Yan,
  • Wentao Kuai,
  • Wei Liu,
  • Kunyan Qiao,
  • Qinghai Dai,
  • Bei Jiang,
  • JianXu,
  • Yu Cao,
  • Kai Ye,
  • Liang Xu,
  • Rui Su

摘要

Aims

This study aims to investigate the prognostic significance of the combined GNR and GPR in patients with early-stage hepatitis B virus-associated hepatocellular carcinoma (HBV-HCC).

Methods

Retrospective analysis was performed on clinical data of 145 HBV-infected patients with early-stage HCC (ESHCC) who underwent radiofrequency ablation (RFA) and/or surgical resection. Patients were randomly allocated to training (n = 103) and validation (n = 42) cohorts for further survival analysis and model verification. The area under the receiver operating characteristic curves (ROC) was used for evaluating the diagnostic performance of ERM-model. And at the optimal cutoff, a survival analysis on all patients was conducted. Simultaneously, all patients were divided into different subgroups to evaluating ERM-Model.

Results

Multivariate Cox analysis identified GNR and GPR as independent risk factors for postoperative intrahepatic recurrence (IHR). The combined biomarkers panel demonstrated superior diagnostic accuracy (AUC = 0.812) compared to AFP (AUC = 0.773). Survival analysis showed a significantly higher 2-year cumulative non-IHR rate in the low-risk group (logit(P) < 0.398) verus the high-risk group (logit(P) ≥ 0.398, p < 0.001). Subgroup analysis of all patients that ERM-model showed differencesin HCC stage stratification, with higher diagnostic accuracy for BCLC stage A cases compared to BCLC stage 0 cases.

Conclusions

GNR and GPR are valuable predictors of IHR in ESHCC. Clinicians can leverage this dual-marker model to assess risk and tailor personalized follow-up strategies.