<p>CD5<sup>+</sup> primary hepatosplenic large B-cell lymphoma (LBCL) is an infrequent disease (Shi et al. in J Int Med Res 48(8):1220737725, 2020; Yamaguchi et al. in Blood 99(3):815–821, 2002; Durani et al. in Leuk Lymphoma 62(13):3078–3086, 2021). Rhupus syndrome is defined as an overlap between systemic lupus erythematosus and rheumatoid arthritis. Here, we presented a rare case of CD5-positive primary hepatosplenic LBCL with rhupus syndrome. The 58-year-old female achieved complete remission after 6 cycles of R-COP and 2 cycles of R-CHOP. Besides, we reviewed case reports of CD5<sup>+</sup> primary hepatosplenic LBCL and speculated the connections between rhupus syndrome and lymphomas.</p>

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CD5+ primary hepatosplenic large B-cell lymphoma and rhupus syndrome in a patient: a case of concurrent diagnosis?

  • Shujun Lin,
  • Jun Yin,
  • Zewen Zhang,
  • Xingxing Wang

摘要

CD5+ primary hepatosplenic large B-cell lymphoma (LBCL) is an infrequent disease (Shi et al. in J Int Med Res 48(8):1220737725, 2020; Yamaguchi et al. in Blood 99(3):815–821, 2002; Durani et al. in Leuk Lymphoma 62(13):3078–3086, 2021). Rhupus syndrome is defined as an overlap between systemic lupus erythematosus and rheumatoid arthritis. Here, we presented a rare case of CD5-positive primary hepatosplenic LBCL with rhupus syndrome. The 58-year-old female achieved complete remission after 6 cycles of R-COP and 2 cycles of R-CHOP. Besides, we reviewed case reports of CD5+ primary hepatosplenic LBCL and speculated the connections between rhupus syndrome and lymphomas.