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<p>Despite advancements in treatment, colorectal cancer (CRC) prevalence, mortality rates, and therapeutic resistance persist as global health concerns. The review delves into metformin’s multifaceted effects on molecular pathways implicated in cancer progression and resistance, including apoptosis, autophagy, epithelial-mesenchymal transition (EMT), and ATP-binding cassette (ABC) transporters. A particular focus is placed on metformin’s promising role in targeting cancer stem cells (CSCs), known for their contribution to chemoresistance, metastasis, and relapse. The potential synergy of metformin with standard CRC treatments, such as chemotherapy and radiotherapy, emerges as a pivotal theme. The review underscores the importance of elucidating metformin’s mechanisms of action and optimizing its utilization through further research, potentially leading to personalized, precision medicine approaches.</p>

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Metformin’s multifaceted role in colorectal cancer: mechanisms of action and synergy with standard treatments

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月7日

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  • Haniye Rahimi Kolour,
  • Nastaran Bahrami,
  • Ehsan Nazemalhosseini-Mojarad,
  • Amir Sadeghi,
  • Mehdi Shamsara,
  • Nayeralsadat Fatemi

摘要

Despite advancements in treatment, colorectal cancer (CRC) prevalence, mortality rates, and therapeutic resistance persist as global health concerns. The review delves into metformin’s multifaceted effects on molecular pathways implicated in cancer progression and resistance, including apoptosis, autophagy, epithelial-mesenchymal transition (EMT), and ATP-binding cassette (ABC) transporters. A particular focus is placed on metformin’s promising role in targeting cancer stem cells (CSCs), known for their contribution to chemoresistance, metastasis, and relapse. The potential synergy of metformin with standard CRC treatments, such as chemotherapy and radiotherapy, emerges as a pivotal theme. The review underscores the importance of elucidating metformin’s mechanisms of action and optimizing its utilization through further research, potentially leading to personalized, precision medicine approaches.