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Background <p>MRPL3, a member of the mitochondrial ribosomal family, is involved in the translation of mitochondria-related proteins. However, its role in tumors remains unclear.</p> Objective <p>To elucidate the oncogenic role and prognostic significance of MRPL3 in cancer.</p> Methods <p>We conducted a pan-cancer analysis of MRPL3 using various databases, bioinformatics and statistical tools, as well as tissue microarray analysis.</p> Results <p>MRPL3 was generally upregulated in tumors compared to normal tissues. Its expression showed a negative correlation with immunogenic markers, immune cell infiltration, and immune checkpoint genes (ICGs) in most cancers, suggesting an immunosuppressive role in the tumor microenvironment (TME). Genes interacting with and similar to MRPL3 were involved in key signaling pathways across cancers. MRPL3 overexpression was frequently associated with poor prognosis and identified as an independent prognostic risk factor in KIRC, LUSC, LIHC, MESO, UCEC, and PAAD.</p> Conclusion <p>MRPL3 is overexpressed in multiple cancers and plays an immunosuppressive role, significantly correlating with poor prognosis, indicating its potential as a therapeutic target in cancer treatment.</p>

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Expressions, immune associations, and prognostic values of mitochondrial ribosomal protein MRPL3 in the pan cancer landscape

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月21日

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  • Jing Lin,
  • Wenzhe Chen,
  • Yaodong Zhao,
  • GuanZhong Qiu

摘要

Background

MRPL3, a member of the mitochondrial ribosomal family, is involved in the translation of mitochondria-related proteins. However, its role in tumors remains unclear.

Objective

To elucidate the oncogenic role and prognostic significance of MRPL3 in cancer.

Methods

We conducted a pan-cancer analysis of MRPL3 using various databases, bioinformatics and statistical tools, as well as tissue microarray analysis.

Results

MRPL3 was generally upregulated in tumors compared to normal tissues. Its expression showed a negative correlation with immunogenic markers, immune cell infiltration, and immune checkpoint genes (ICGs) in most cancers, suggesting an immunosuppressive role in the tumor microenvironment (TME). Genes interacting with and similar to MRPL3 were involved in key signaling pathways across cancers. MRPL3 overexpression was frequently associated with poor prognosis and identified as an independent prognostic risk factor in KIRC, LUSC, LIHC, MESO, UCEC, and PAAD.

Conclusion

MRPL3 is overexpressed in multiple cancers and plays an immunosuppressive role, significantly correlating with poor prognosis, indicating its potential as a therapeutic target in cancer treatment.