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<p>Heparanase 2 (Hpa2), a homolog of heparinase, lacks the conventional heparinase activity associated with heparin degradation. However, it exhibits a greater affinity for heparin sulfate (HS) compared to heparinase. In our study, overexpression of Hpa2 significantly inhibited the viability, migration, and invasion of gallbladder cancer cells, both in vivo and in vitro. Moreover, this inhibitory effect of Hpa2 was reversed upon administration of agonists targeting the VEGF/VEGFR pathway. These findings suggest that Hpa2 overexpression may impede the growth of NOZ cells, potentially through modulation of the VEGF/VEGFR signaling pathway.</p>

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Heparanase2 inhibits the growth of gallbladder cancer by regulating the VEGF/VEGFR pathway

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月15日

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  • Dengyi Cao,
  • Jiawei Chen,
  • Shaobo Zhou,
  • Jie Tang,
  • Zixiang Liu,
  • Zixiang Zhang

摘要

Heparanase 2 (Hpa2), a homolog of heparinase, lacks the conventional heparinase activity associated with heparin degradation. However, it exhibits a greater affinity for heparin sulfate (HS) compared to heparinase. In our study, overexpression of Hpa2 significantly inhibited the viability, migration, and invasion of gallbladder cancer cells, both in vivo and in vitro. Moreover, this inhibitory effect of Hpa2 was reversed upon administration of agonists targeting the VEGF/VEGFR pathway. These findings suggest that Hpa2 overexpression may impede the growth of NOZ cells, potentially through modulation of the VEGF/VEGFR signaling pathway.