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Background <p>Upper extremity lymphedema, a major complication post-breast cancer surgery, severely impacts quality of life. While body mass index (BMI) is suggested as a risk factor for postoperative breast cancer-related lymphedema (BCRL), evidence is inconsistent. This meta-analysis systematically evaluates BMI’s impact on postoperative lymphedema to resolve discrepancies and provide accurate insights.</p> Methods <p>The authors conducted comprehensive literature searches from inception to October 7, 2024, in major English-language databases, including PubMed, Embase, and Cochrane. To assess the association between BMI and postoperative BCRL, odds ratio (OR) with 95% confidence intervals (95% CI) were calculated. Subgroup analyses were also performed to evaluate the impact of BMI on postoperative lymphedema in breast cancer patients across different geographic regions.</p> Results <p>This meta-analysis included 16 studies involving 6,057 postoperative breast cancer patients, with sample sizes ranging from 101 to 1,130. The results revealed a significant association between elevated BMI and postoperative BCRL, with an OR of 2.05 (95% CI, 1.53–2.75; <i>P</i> &lt; 0.005) for patients with BMI ≥ 25&#xa0;kg/m² compared to those with BMI &lt; 25&#xa0;kg/m². These findings underscore a significant positive correlation between higher BMI and an increased risk of postoperative lymphedema in breast cancer patients.</p> Conclusions <p>Our findings demonstrate that a BMI ≥ 25&#xa0;kg/m² is a significant risk factor for postoperative lymphedema in breast cancer patients. A comprehensive understanding of BMI’s role in lymphedema development post-surgery can inform clinicians and therapists in designing personalized strategies to mitigate this complication.</p>

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Effect of body mass index on postoperative lymphedema after breast cancer: a systematic review and meta-analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月29日

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  • Weiwei Zhang,
  • Zhilin Liu,
  • Jinming Li,
  • Hengheng Zhang,
  • Meijie Wu,
  • Ping Yang,
  • Tao Wu,
  • Guoshuang Shen,
  • Fuxing Zhao,
  • Zhen Liu

摘要

Background

Upper extremity lymphedema, a major complication post-breast cancer surgery, severely impacts quality of life. While body mass index (BMI) is suggested as a risk factor for postoperative breast cancer-related lymphedema (BCRL), evidence is inconsistent. This meta-analysis systematically evaluates BMI’s impact on postoperative lymphedema to resolve discrepancies and provide accurate insights.

Methods

The authors conducted comprehensive literature searches from inception to October 7, 2024, in major English-language databases, including PubMed, Embase, and Cochrane. To assess the association between BMI and postoperative BCRL, odds ratio (OR) with 95% confidence intervals (95% CI) were calculated. Subgroup analyses were also performed to evaluate the impact of BMI on postoperative lymphedema in breast cancer patients across different geographic regions.

Results

This meta-analysis included 16 studies involving 6,057 postoperative breast cancer patients, with sample sizes ranging from 101 to 1,130. The results revealed a significant association between elevated BMI and postoperative BCRL, with an OR of 2.05 (95% CI, 1.53–2.75; P < 0.005) for patients with BMI ≥ 25 kg/m² compared to those with BMI < 25 kg/m². These findings underscore a significant positive correlation between higher BMI and an increased risk of postoperative lymphedema in breast cancer patients.

Conclusions

Our findings demonstrate that a BMI ≥ 25 kg/m² is a significant risk factor for postoperative lymphedema in breast cancer patients. A comprehensive understanding of BMI’s role in lymphedema development post-surgery can inform clinicians and therapists in designing personalized strategies to mitigate this complication.