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<p>Epithelial tissues maintain homeostasis by employing sophisticated mechanisms to promote clearance of precancerous cells, thus preventing tumorigenesis. Two key processes—cell competition and extrusion—collectively termed epithelial defense against cancer (EDAC), enable normal epithelial cells to outcompete or physically expel transformed counterparts. This review integrates recent advances in EDAC, detailing critical proteins, biomechanical cues, and their interplay with immune surveillance. We quantify cellular proportions essential for EDAC efficacy and examine cancer models, focusing on pancreatic, colorectal, and mammary cancers. By linking molecular mechanisms to clinical potential, we position EDAC as a promising frontier for cancer prevention and therapy.</p>

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Epithelial guardians against cancer: integrating cell competition and extrusion in early tumor control

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月9日

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  • Grecia Riofrio-Chung,
  • César Rivera

摘要

Epithelial tissues maintain homeostasis by employing sophisticated mechanisms to promote clearance of precancerous cells, thus preventing tumorigenesis. Two key processes—cell competition and extrusion—collectively termed epithelial defense against cancer (EDAC), enable normal epithelial cells to outcompete or physically expel transformed counterparts. This review integrates recent advances in EDAC, detailing critical proteins, biomechanical cues, and their interplay with immune surveillance. We quantify cellular proportions essential for EDAC efficacy and examine cancer models, focusing on pancreatic, colorectal, and mammary cancers. By linking molecular mechanisms to clinical potential, we position EDAC as a promising frontier for cancer prevention and therapy.