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<p>Pyroptosis is a novel form of programmed cell death that depends on gasdermin-mediated pore formation in the plasma membrane and the release of inflammatory factors. Pyroptosis is closely linked to the occurrence and progression of almost all types of cancer, including ovarian cancer, which is the seventh most common malignancy among women worldwide and poses a significant threat to women’s health. Research indicates that pyroptosis may offer potential strategies for monitoring and treating ovarian cancer. This review systematically discusses the molecular mechanisms of pyroptosis and its role in the onset, progression, prognosis, and treatment of ovarian cancer, providing deep insights for further research in this field.</p>

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The role of pyroptosis in ovarian cancer

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月3日

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  • Yingzhi Zhou,
  • Tian Peng,
  • Jiahan Zhang,
  • Ruojia Liang

摘要

Pyroptosis is a novel form of programmed cell death that depends on gasdermin-mediated pore formation in the plasma membrane and the release of inflammatory factors. Pyroptosis is closely linked to the occurrence and progression of almost all types of cancer, including ovarian cancer, which is the seventh most common malignancy among women worldwide and poses a significant threat to women’s health. Research indicates that pyroptosis may offer potential strategies for monitoring and treating ovarian cancer. This review systematically discusses the molecular mechanisms of pyroptosis and its role in the onset, progression, prognosis, and treatment of ovarian cancer, providing deep insights for further research in this field.