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Objectives <p>To evaluate c-met expression as a reliable prognostic indicator for survival in esophageal cancer patients.</p> Methods <p>Eligible articles from relevant studies or databases were retrieved via systematical search. The association between c-met expression and survival results was evaluated by pooled effect in esophageal cancer patients. A fixed-effects or random-effects model was used to calculate the pooled risk ratios (RRs) and corresponding 95% confidence intervals (CIs).</p> Results <p>13 studies were up to the selection criteria. Our meta-analysis indicated that c-met positive expression correlated with lower overall survival (RR = 0.40; 95%CI: 0.25–0.63), disease-free-survival (RR = 0.30; 95%CI: 0.21–0.44), disease specific survival (RR = 0.53; 95%CI: 0.35–0.80) in esophageal cancer patients.</p> Conclusion <p>C-met positive expression indicates a poor prognosis in esophageal cancer patients. Further studies are required to confirm our result.</p>

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Systematic review of c-met as a prognostic indicator in esophageal cancer patients: a meta-analysis study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月26日

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  • Zipu Yu,
  • Guofei Zhang,
  • Gang Shen

摘要

Objectives

To evaluate c-met expression as a reliable prognostic indicator for survival in esophageal cancer patients.

Methods

Eligible articles from relevant studies or databases were retrieved via systematical search. The association between c-met expression and survival results was evaluated by pooled effect in esophageal cancer patients. A fixed-effects or random-effects model was used to calculate the pooled risk ratios (RRs) and corresponding 95% confidence intervals (CIs).

Results

13 studies were up to the selection criteria. Our meta-analysis indicated that c-met positive expression correlated with lower overall survival (RR = 0.40; 95%CI: 0.25–0.63), disease-free-survival (RR = 0.30; 95%CI: 0.21–0.44), disease specific survival (RR = 0.53; 95%CI: 0.35–0.80) in esophageal cancer patients.

Conclusion

C-met positive expression indicates a poor prognosis in esophageal cancer patients. Further studies are required to confirm our result.