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Background <p>Excessive abundance of gut pathogens and inflammatory lung damage are potential risk factors for lung cancer. Nevertheless, the exact function of inflammatory proteins in mediating the nexus between gut microbiota and lung cancer remains elusive.</p> Methods <p>We first executed Mendelian randomization analysis with the inverse variance weighting method as the primary method, followed by a sensitivity analysis of the results. Finally, we carried out in vitro experiments and database analyses to corroborate our conclusions.</p> Results <p>After multiple tests, we identified that the gut genus <i>Parasutterella</i> and species <i>Escherichia coli</i> (<i>E. coli</i>) were tied a heightened risk of lung cancer, while <i>Bacteroides salyersiae</i> was a protective factor against lung cancer. Circulating STAM-binding protein (STAMBP) and C–C Motif Chemokine Ligand 23 were considered potential risk factors for lung cancer. In vitro experimental results indicated that the <i>E. coli</i> supernatant significantly induced lung cancer cell proliferation and cell cycle transition but suppressed cell apoptosis. Mechanistically, <i>E. coli</i> increases the production of STAMBP to promote lung cancer progression.</p> Conclusions <p>Our results indicated that gut <i>E. coli</i> can potentially increase STAMBP secretion, thereby promoting lung cancer progression. This research delivers a new viewpoint for analyzing the carcinogenic mechanism of <i>E. coli</i> as well as the subsequent prevention and management of lung cancer.</p>

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Gut Escherichia coli promotes lung cancer by increasing circulating STAMBP production

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月3日

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  • Xinpei Li,
  • You Mo,
  • Shijie Shang,
  • Meng Wu,
  • Shuling Ma,
  • Zijun Zhai,
  • Qian Song,
  • Dawei Chen

摘要

Background

Excessive abundance of gut pathogens and inflammatory lung damage are potential risk factors for lung cancer. Nevertheless, the exact function of inflammatory proteins in mediating the nexus between gut microbiota and lung cancer remains elusive.

Methods

We first executed Mendelian randomization analysis with the inverse variance weighting method as the primary method, followed by a sensitivity analysis of the results. Finally, we carried out in vitro experiments and database analyses to corroborate our conclusions.

Results

After multiple tests, we identified that the gut genus Parasutterella and species Escherichia coli (E. coli) were tied a heightened risk of lung cancer, while Bacteroides salyersiae was a protective factor against lung cancer. Circulating STAM-binding protein (STAMBP) and C–C Motif Chemokine Ligand 23 were considered potential risk factors for lung cancer. In vitro experimental results indicated that the E. coli supernatant significantly induced lung cancer cell proliferation and cell cycle transition but suppressed cell apoptosis. Mechanistically, E. coli increases the production of STAMBP to promote lung cancer progression.

Conclusions

Our results indicated that gut E. coli can potentially increase STAMBP secretion, thereby promoting lung cancer progression. This research delivers a new viewpoint for analyzing the carcinogenic mechanism of E. coli as well as the subsequent prevention and management of lung cancer.