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Objectives <p>To evaluate the efficacy and safety of thermal ablation (TA) for follicular thyroid neoplasms (FTN) ≤ 3&#xa0;cm.</p> Methods <p>This retrospective multicenter study enrolled 161 patients (131 females; mean age, 46 ± 15&#xa0;years [range, 11–86]) who underwent TA for FTN ≤ 3&#xa0;cm between January 2014 and October 2023 from eight centers in China. The median follow-up time was 12&#xa0;months (IQR, 12–24&#xa0;months). Based on the maximum diameter (MD) of the nodule, patients were divided into two groups: Group 1 (MD ≤ 2&#xa0;cm) and Group 2 (2 &lt; MD ≤ 3&#xa0;cm). Post-ablation assessments encompassed evaluations of tumor size and volume changes, technical success rate, tumor disappearance, disease progression, complications, and risk factors associated with recurrent laryngeal nerve (RLN) injury.</p> Results <p>All patients underwent complete ablation in a single session. The technical success rate was 100%. The mean volume reduction rate (VRR) of the ablation zone at 12&#xa0;months was 78.11%. The VRR at 12&#xa0;months was higher in Group 1 than that in Group 2 (Median VRR, 93.8% vs. 82.8%; P = 0.019). The complete tumor disappearance rate was 15.5% (25/161). Smaller tumors have a higher tumor disappearance rate (Group 1 vs Group 2 = 27.6% vs. 4.7%; P &lt; 0.001). The disease progression rate was 2.5% (4/161), with no significant difference between Group 1 and Group 2 (P = 0.535). The complication rate was 3.1% (5/161), with no significant difference between Group 1 and Group 2 (P = 0.899). No risk factors were identified for RLN injury.</p> Conclusions <p>Thermal ablation is an effective and safe treatment option for patients with FTN ≤ 3&#xa0;cm.</p>

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The preliminary multicenter retrospective study on the efficacy and safety of thermal ablation for follicular thyroid neoplasms ≤ 3 cm

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月20日

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  • Yu-tong Liu,
  • Bo-Qiang Fan,
  • Jun-feng He,
  • Ying Zhou,
  • Song-song Wu,
  • Shu-rong Wang,
  • Gang Dong,
  • Jian-qin Guo,
  • Ying Wei,
  • Zhen-Long Zhao,
  • Jie Wu,
  • Shi-Liang Cao,
  • Na Yu,
  • Yan Li,
  • Li-Li Peng,
  • Ming-an Yu

摘要

Objectives

To evaluate the efficacy and safety of thermal ablation (TA) for follicular thyroid neoplasms (FTN) ≤ 3 cm.

Methods

This retrospective multicenter study enrolled 161 patients (131 females; mean age, 46 ± 15 years [range, 11–86]) who underwent TA for FTN ≤ 3 cm between January 2014 and October 2023 from eight centers in China. The median follow-up time was 12 months (IQR, 12–24 months). Based on the maximum diameter (MD) of the nodule, patients were divided into two groups: Group 1 (MD ≤ 2 cm) and Group 2 (2 < MD ≤ 3 cm). Post-ablation assessments encompassed evaluations of tumor size and volume changes, technical success rate, tumor disappearance, disease progression, complications, and risk factors associated with recurrent laryngeal nerve (RLN) injury.

Results

All patients underwent complete ablation in a single session. The technical success rate was 100%. The mean volume reduction rate (VRR) of the ablation zone at 12 months was 78.11%. The VRR at 12 months was higher in Group 1 than that in Group 2 (Median VRR, 93.8% vs. 82.8%; P = 0.019). The complete tumor disappearance rate was 15.5% (25/161). Smaller tumors have a higher tumor disappearance rate (Group 1 vs Group 2 = 27.6% vs. 4.7%; P < 0.001). The disease progression rate was 2.5% (4/161), with no significant difference between Group 1 and Group 2 (P = 0.535). The complication rate was 3.1% (5/161), with no significant difference between Group 1 and Group 2 (P = 0.899). No risk factors were identified for RLN injury.

Conclusions

Thermal ablation is an effective and safe treatment option for patients with FTN ≤ 3 cm.