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Background <p>Circular RNAs (circRNAs) are increasingly recognized for their potential as cancer biomarkers. Although various studies have investigated the biological function of ciRS-7 and circHIPK3 in malignant tumors, their prognostic value in pan-cancer has not been systematically analyzed.</p> Methods <p>We systematically searched the PubMed, Web of Science, and Cochrane Library databases from January 1, 1990, to October 14, 2024. The impact of ciRS-7 or circHIPK3 on prognostic outcomes, including overall survival (OS) and disease-free survival (DFS), was assessed by pooled hazard ratios (HR). The association between CiRS-7 or circHIPK3 and clinical features was evaluated using odds ratios (OR). The Data analysis was conducted using Review Manager 5.4.</p> Results <p>For most cancers, our meta-analysis of 14 studies (N = 2140) and 15 studies (N = 1045) showed that high ciRS-7 and circHIPK3 were associated with worse OS. Pooled analysis of 5 studies (N = 421) and 2 studies (N = 248) indicated that high ciRS-7 and circHIPK3 were also associated with shorter DFS. Additionally, high ciRS-7 and circHIPK3 expression were associated with worse histological grade, higher TNM stage, larger tumor size, more lymph node and distant metastasis.</p> Conclusion <p>High ciRS-7 and circHIPK3 were significantly associated with poor prognosis and advanced clinical features in most cancers, suggesting their potential as prognostic biomarkers.</p>

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The prognosis of ciRS-7 and circHIPK3 in pan-cancer: a mini-review and meta-analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月19日

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  • Xiangji Li,
  • Tong Wu,
  • Ruihan Dong,
  • Xiaoying Wu

摘要

Background

Circular RNAs (circRNAs) are increasingly recognized for their potential as cancer biomarkers. Although various studies have investigated the biological function of ciRS-7 and circHIPK3 in malignant tumors, their prognostic value in pan-cancer has not been systematically analyzed.

Methods

We systematically searched the PubMed, Web of Science, and Cochrane Library databases from January 1, 1990, to October 14, 2024. The impact of ciRS-7 or circHIPK3 on prognostic outcomes, including overall survival (OS) and disease-free survival (DFS), was assessed by pooled hazard ratios (HR). The association between CiRS-7 or circHIPK3 and clinical features was evaluated using odds ratios (OR). The Data analysis was conducted using Review Manager 5.4.

Results

For most cancers, our meta-analysis of 14 studies (N = 2140) and 15 studies (N = 1045) showed that high ciRS-7 and circHIPK3 were associated with worse OS. Pooled analysis of 5 studies (N = 421) and 2 studies (N = 248) indicated that high ciRS-7 and circHIPK3 were also associated with shorter DFS. Additionally, high ciRS-7 and circHIPK3 expression were associated with worse histological grade, higher TNM stage, larger tumor size, more lymph node and distant metastasis.

Conclusion

High ciRS-7 and circHIPK3 were significantly associated with poor prognosis and advanced clinical features in most cancers, suggesting their potential as prognostic biomarkers.