Scholarlink

Background <p>Lung cancer is the second most prevalent malignancy among males and females and the leading cause of cancer deaths. Due to its high mortality, identification of novel therapeutic options is of critical value. Regulatory T cells and their associated transcripts are among possible targets for design of targeted therapies.</p> Methods <p>Here, we assessed expression of lncRNAs that are possibly involved in Treg lineage commitment and their plasticity in lung tumor tissues (TT) and normal tissues adjacent to the tumor (NTAT).</p> Results <p>We found up-regulation of TH2-LCR, IFNG-AS1, and MAFTRR in TT samples compared with NTATs. The highest difference in the expression between two sets of samples belonged to MAFTRR with expression ratio (95% CI) of 6.48 (2.67–15.7). TH2-LCR ranked second in this list with expression ratio (95% CI) of 5.23 (1.92–14.24). Finally, IFNG-AS1 was up-regulated in TT samples compared with NTATs with expression ratio (95% CI) of 3.3 (1.56–6.95). Then, the suitability of MAFTRR, TH2-LCR and IFNG-AS1 in the separation of TT samples from NTATs was assessed through plotting sensitivity values against 1-specifiicity values in ROC curves. The obtained AUC values were 0.74, 0.71 and 0.7, respectively.</p> Conclusion <p>In brief, we demonstrated dysregulation of three Treg-related lncRNAs in lung cancer tissues and suggested them as possible candidates for biomarker discovery investigations.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Tissue levels of regulatory T cell related lncRNAs in lung cancer: evidence for dysregulation of immune responses

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年2月21日

查看全文
  • Farbod Esfandi,
  • Bashdar Mahmud Hussen,
  • Ali Shakeri Abroudi,
  • Melika Djamali,
  • Solat Eslami,
  • Fatemeh Sadat Feghahati,
  • Arezou Sayad,
  • Soudeh Ghafouri-Fard

摘要

Background

Lung cancer is the second most prevalent malignancy among males and females and the leading cause of cancer deaths. Due to its high mortality, identification of novel therapeutic options is of critical value. Regulatory T cells and their associated transcripts are among possible targets for design of targeted therapies.

Methods

Here, we assessed expression of lncRNAs that are possibly involved in Treg lineage commitment and their plasticity in lung tumor tissues (TT) and normal tissues adjacent to the tumor (NTAT).

Results

We found up-regulation of TH2-LCR, IFNG-AS1, and MAFTRR in TT samples compared with NTATs. The highest difference in the expression between two sets of samples belonged to MAFTRR with expression ratio (95% CI) of 6.48 (2.67–15.7). TH2-LCR ranked second in this list with expression ratio (95% CI) of 5.23 (1.92–14.24). Finally, IFNG-AS1 was up-regulated in TT samples compared with NTATs with expression ratio (95% CI) of 3.3 (1.56–6.95). Then, the suitability of MAFTRR, TH2-LCR and IFNG-AS1 in the separation of TT samples from NTATs was assessed through plotting sensitivity values against 1-specifiicity values in ROC curves. The obtained AUC values were 0.74, 0.71 and 0.7, respectively.

Conclusion

In brief, we demonstrated dysregulation of three Treg-related lncRNAs in lung cancer tissues and suggested them as possible candidates for biomarker discovery investigations.