Real world experience with MET inhibitors in MET exon 14 skipping mutated non-small cell lung cancer: largest Indian perspective
摘要
Patients with Non-small Cell Lung Cancer (NSCLC) presenting with Mesenchymal–epithelial transition exon 14 skipping mutation (MET ex14) have an unfavorable prognosis with traditional therapies. MET inhibitors have altered the therapeutic paradigm of NSCLC. MET ex14 skipping alteration is reported in 3–4% cases (N Engl J Med 383(10):944-957, 2020, Cancer Discov 5(8):842-9, 2015). Randomized controlled trials have reported noteworthy outcomes of selective MET tyrosine kinase inhibitors (TKIs), however real-world data from the Indian sub-continent is lacking.
MethodsThe current study is a non-interventional retrospective multi-centre analysis reporting on real-world data of NSCLC patients with MET ex14 skipping alteration from two apex cancer centers from India. Data of 49 eligible NSCLC patients with MET ex14 mutations fulfilling the inclusion and exclusion criteria were reviewed and analysed. Kaplan Meier (KM) estimating method was used to estimate the overall survival (OS) and progression free survival (PFS). Log rank test was used to compare the survival curves between the groups. A p-value < 0.05 was considered clinically significant. Statistical analysis was performed using R studio.
ResultsA total of 49 patients harboring MET ex14 alterations were included in the current study. Table
The current study comprises of the largest MET ex14 mutated NSCLC patient cohort reporting on the real-world data of MET TKI therapy from the Indian subcontinent. MET TKI showed higher systemic and intracranial efficacy with manageable safety profile. The current study represents an unmet need for more clinical phase 3 study for rare genomic alterations as well as patient access programs in the Indian subcontinent.