<p>Compassion-based meditation practices, including Tonglen, offer promise for emotional self-regulation, yet Tonglen remains underutilized in contemporary clinical and applied settings. This paper introduces Hope Breath, a brief three-minute adaptation of Tonglen meditation designed to simultaneously downregulate negative emotions and upregulate positive states. The aim was to provide practitioners with a protocol for immediate application, grounded in the empirical and theoretical literature on Tonglen, compassion-based meditation, and brief mindfulness-based interventions. The Hope Breath protocol is presented as a practitioner guidelines paper. A composite clinical vignette is provided to illustrate the technique’s application and observed outcomes. Hope Breath combines Tonglen-style breathwork, cloud visualization, transcendent connection, and positive word recitation into an accessible three-minute practice. A composite clinical vignette illustrates the technique’s application and describes self-reported shifts from distress to attentiveness. Practitioner guidance is provided covering implementation, contraindications, common difficulties, and ethical considerations for teaching. Hope Breath offers practitioners a brief, accessible tool for in-the-moment emotional regulation that is grounded in the Tonglen tradition. The protocol may be of particular value for healthcare workers at risk for compassion fatigue.</p>