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Objectives <p>Mindfulness interventions have demonstrated significant effectiveness in alleviating perioperative symptoms, but how they impact the interconnected symptom network and hospital outcomes remains unclear. This study explored the effect of Perioperative Mindfulness Intervention (PMI) on symptom networks and hospital-related outcomes of patients with gastrointestinal cancer.</p> Method <p>A sample of 328 patients with gastrointestinal cancer was randomly allocated to the intervention (<i>n</i> = 164) or control group (<i>n</i> = 164). The PMI, delivered via WeChat, comprised seven sessions during the perioperative period, integrating health education and mindfulness practice through multimedia content. The main measurement tools included the M.D. Anderson Symptom Inventory-Gastrointestinal Cancer Module, the Quality of Recovery-15, and the Stress Response Questionnaire. We conducted assessments before (T0, 2&#xa0;days before surgery), during (T1, 2&#xa0;days after surgery and T2, 6&#xa0;days after surgery), immediately after (T3, 10&#xa0;days after surgery), and 4&#xa0;days after the mindfulness intervention (T4, 14&#xa0;days after surgery). The main methods included the Network Comparison Test (NCT) and Network Intervention Analysis (NIA).</p> Results <p>The NCT revealed differences in network structure, global strength, and the centrality of certain nodes between the two symptom networks<i>.</i> The NIA identified the targets of mindfulness intervention during the perioperative period including dry mouth, sleep disturbances, and pain. Moreover, there were differences in recovery quality (<i>t</i>(326) = − 3.23, <i>p</i> = 0.001, Cohen’s <i>d</i> = − 0.36), adaptation status (<i>t</i>(322.61) = 4.92, <i>p</i> &lt; 0.001, Cohen’s <i>d</i> = 0.54), and length of hospital stay (<i>t</i>(311.33) = 2.63, <i>p</i> = 0.009, Cohen’s <i>d</i> = 0.30) between the two groups.</p> Conclusions <p>This research was expected to not only enhance patients’ recovery quality and adaptation, shorten hospital stays, but also improve medical service quality.</p> Preregistration <p>The trial was prospectively registered at the Chinese Clinical Trial Registry (ChiCTR2100044752) on March 26, 2021.</p>

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Effect of Perioperative Mindfulness Intervention on Symptom Network and Hospital Outcomes in Patients with Gastrointestinal Cancer: A Randomized Controlled Trial

  • 期刊论文

  • 发表日期：

    2026年5月18日

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  • Gaorong Lv,
  • Xinyi Liu,
  • Xiyu Bao,
  • Meiling Qi,
  • Ping Li

摘要

Objectives

Mindfulness interventions have demonstrated significant effectiveness in alleviating perioperative symptoms, but how they impact the interconnected symptom network and hospital outcomes remains unclear. This study explored the effect of Perioperative Mindfulness Intervention (PMI) on symptom networks and hospital-related outcomes of patients with gastrointestinal cancer.

Method

A sample of 328 patients with gastrointestinal cancer was randomly allocated to the intervention (n = 164) or control group (n = 164). The PMI, delivered via WeChat, comprised seven sessions during the perioperative period, integrating health education and mindfulness practice through multimedia content. The main measurement tools included the M.D. Anderson Symptom Inventory-Gastrointestinal Cancer Module, the Quality of Recovery-15, and the Stress Response Questionnaire. We conducted assessments before (T0, 2 days before surgery), during (T1, 2 days after surgery and T2, 6 days after surgery), immediately after (T3, 10 days after surgery), and 4 days after the mindfulness intervention (T4, 14 days after surgery). The main methods included the Network Comparison Test (NCT) and Network Intervention Analysis (NIA).

Results

The NCT revealed differences in network structure, global strength, and the centrality of certain nodes between the two symptom networks. The NIA identified the targets of mindfulness intervention during the perioperative period including dry mouth, sleep disturbances, and pain. Moreover, there were differences in recovery quality (t(326) = − 3.23, p = 0.001, Cohen’s d = − 0.36), adaptation status (t(322.61) = 4.92, p < 0.001, Cohen’s d = 0.54), and length of hospital stay (t(311.33) = 2.63, p = 0.009, Cohen’s d = 0.30) between the two groups.

Conclusions

This research was expected to not only enhance patients’ recovery quality and adaptation, shorten hospital stays, but also improve medical service quality.

Preregistration

The trial was prospectively registered at the Chinese Clinical Trial Registry (ChiCTR2100044752) on March 26, 2021.