Objectives <p>Termination of pregnancy for fetal abnormalities (TOPFA) is associated with considerable psychological distress, particularly anxiety and depression. However, evidence on mindfulness-based interventions (MBIs) for parents undergoing TOPFA remains limited, especially for dyadic approaches. This study investigated the effects of a mindfulness-based couple-centered intervention (MBCI) on mindfulness, anxiety, and depression in this population.</p> Method <p>This study was a randomized, controlled, parallel-group clinical trial, 120 parents who underwent TOPFA were randomly allocated to either the intervention group (<i>n</i> = 60) or the control group (<i>n</i> = 60). A total of 97 participants (age range: 24–49&#xa0;years; 60% university-educated) completed the Generalized Anxiety Disorder Scale, the Patient Health Questionnaire, and the Mindfulness Attention Awareness Scale at baseline (T1) and post-intervention (T2).</p> Results <p>Compared with the control group, the intervention group demonstrated significantly elevated mindfulness (<i>t</i> = -2.07, <i>p</i> = 0.04) and reduced anxiety (<i>Z</i> = -3.18, <i>p</i> &lt; 0.01) /depression (<i>Z</i> = -2.11, <i>p</i> = 0.04). In contrast, no significant pre-post changes were observed in the control group across any measures. Despite a non-significant increase in the intervention group's mindfulness levels from pre-test to post-test (<i>Z</i> = -1.57, <i>p</i> = 0.12), participants had significant reductions in anxiety (<i>Z</i> = -3.07, <i>p</i> &lt; 0.01) and depression (<i>Z</i> = -2.85, <i>p</i> &lt; 0.01).</p> Conclusions <p>The findings of this study suggest that MBCI may improve mindfulness and reduce anxiety and depression among parents experiencing TOPFA. Larger studies with longer follow-up are needed to further evaluate its long-term effects.</p>