Objectives <p>Mindfulness has become increasingly incorporated into pain management, reflecting growing awareness of the cognitive and emotional dimensions of pain perception. This bibliometric study aimed to map global research trends, identify influential contributors, and highlight emerging areas of inquiry related to mindfulness and pain between 2000 and 2024.</p> Method <p>Publications and reviews related to mindfulness for pain from January 2000 to July 2024 were retrieved from the Web of Science Core Collection database. Data visualization and analysis were conducted using CiteSpace, VOSviewer, and Scimago Graphica to explore key contributors and research themes, revealing the intellectual structure and evolution of the field.</p> Results <p>A total of 643 articles were identified, showing a steady increase in research output across the study period. The USA contributed the largest number of publications, while <i>Pain</i> was the most productive outlet. High-frequency keywords included “mindfulness,” “meditation,” and “chronic pain” indicating sustained interest in both conceptual development and clinical application.</p> Conclusions <p>This bibliometric study systematically mapped the global evolution of research on mindfulness for pain from 2000 to 2024 and revealed sustained growth alongside a clear shift from clinical validation toward mechanistic and interdisciplinary inquiry. The main research frontiers include headache and migraine, chronic low back pain, fibromyalgia, cancer-related pain, and neurobiological mechanisms, reflecting the expanding role of mindfulness as a comprehensive, non-pharmacological strategy for pain management.</p>