Objectives <p>Mindfulness-integrated Cognitive Behaviour Therapy (MiCBT) is a novel mindfulness-based intervention (MBI) that aims to achieve a transdiagnostic effect through interoceptive desensitisation. Although the first MiCBT manual was published over a decade ago, no structured review of its evidence base has been undertaken. This scoping review summarises the existing literature, evaluates MiCBT’s effectiveness across outcomes and contexts, and identifies areas of future research.</p> Method <p>A comprehensive search of six databases (MEDLINE, PsycINFO, Web of Science, Embase, CINHAL, and Scopus) and the grey literature was conducted to identify studies comparing MiCBT to a control comparator. Study selection, data extraction, and analysis were carried out according to the JBI methodology for scoping reviews.</p> Results <p>Fourteen studies met the inclusion criteria. Synthesis of findings suggests that MiCBT is an effective treatment across a wide spectrum of psychological and physical conditions in culturally diverse and co-morbid populations. Multiple randomised controlled trials reported benefits for depression, anxiety, and a range of outcomes in people with co-morbid relapsing–remitting multiple sclerosis and breast cancer.</p> Conclusions <p>The literature suggests that interoceptive desensitisation through MiCBT is effective across diverse outcomes, cultural settings, and co-morbidities. MiCBT may offer a valuable alternative to existing psychotherapy modalities, particularly for individuals who prefer this approach or in cases where treatment outcomes may respond better to this process of change. This review highlights areas for future research, including using gold standard comparators, investigating adverse effects, and broadening populations studied further.</p>