Objectives <p>A systematic review was conducted to evaluate the efficacy of mindfulness-based interventions (MBIs) to reduce stress and related outcomes in Latinx college students. Despite decades of research, less is known about the efficacy of MBIs in reducing stress among this population, given their negligible representation in previous studies.</p> Method <p>Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic literature search was conducted across six databases through June 2023. Eligible studies measured stress and related outcomes, had baseline and follow-up assessments, and included Latinx college students. Excluded studies lacked an intervention, targeted medical or nursing students, did not report stress measures, were conducted outside of the U.S., and did not report including Latinx students.</p> Results <p>A total of 15 studies were identified. Findings indicate that most MBIs resulted in significant changes in stress reduction, mindfulness, anxiety, and improved GPAs. Among these studies, two “focal studies” reported samples of 50% or greater Latinx college students. These studies included 70 students, and reported significant decreases in BMI and an increase in self-compassion, mindfulness, and walking behavior.</p> Conclusions <p>This review highlights the effectiveness of MBIs for stress reduction among Latinx college students. Future studies should report recruitment efforts, incentives, attrition, and outcomes by demographic subgroup in order to understand the differing barriers and opportunities for reaching and serving historically underserved groups. As MBIs are adapted to diverse populations, assessment of population-specific needs and impact will benefit researchers’ understanding of program efficacy.</p> Preregistration <p>This study is not preregistered.</p>