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<p>This work demonstrates a highly efficient and environmentally benign synthesis of novel 2-amino-indeno-pyrimidinone analogues via a one-pot, three-component reaction of substituted aldehydes, indane-1,3-dione, and guanidinium hydrochloride. The reaction was conducted under solvent-free conditions using a mortar and pestle grinding technique at room temperature, affording the target compounds in excellent yields (91–97%). All synthesized derivatives were thoroughly characterized by spectroscopic methods, including <sup>1</sup>H NMR, <sup>13</sup>C NMR, and high-resolution mass spectrometry (HRMS). The present methodology offers notable advantages such as mild reaction conditions, catalyst-free operation, simple grinding, short reaction time, exceptional yields, minimal environmental impact, and straightforward workup procedures.</p>

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Developing a Sustainable Mechanochemical Route to Bio-Relevant 2-Amino-Indeno-Pyrimidinone Scaffolds

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月10日

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  • Bathala Balaramudu,
  • Chunduri Venkata Rao,
  • Reda A. Haggam,
  • Suresh Maddila

摘要

This work demonstrates a highly efficient and environmentally benign synthesis of novel 2-amino-indeno-pyrimidinone analogues via a one-pot, three-component reaction of substituted aldehydes, indane-1,3-dione, and guanidinium hydrochloride. The reaction was conducted under solvent-free conditions using a mortar and pestle grinding technique at room temperature, affording the target compounds in excellent yields (91–97%). All synthesized derivatives were thoroughly characterized by spectroscopic methods, including 1H NMR, 13C NMR, and high-resolution mass spectrometry (HRMS). The present methodology offers notable advantages such as mild reaction conditions, catalyst-free operation, simple grinding, short reaction time, exceptional yields, minimal environmental impact, and straightforward workup procedures.