Scholarlink

<p>Nanotechnology has emerged as a rapidly expanding field with broad applications across biomedical, environmental, and industrial sectors. Among nanomaterials, zinc phosphate nanoparticles have gained increasing attention due to their biocompatibility, biosafety, low toxicity, and environmental compatibility. In the present study, zinc phosphate nanoparticles (Zn₃(PO₄)₂ NPs) were chemically synthesized using a low-temperature method, followed by comprehensive physicochemical characterization. The morphology and nanoscale dimensions (~ 43&#xa0;nm) of the dehydrated nanoparticles were examined using transmission electron microscopy, while elemental composition, crystallinity, surface charge, and dispersion behavior were assessed using EDX, XRD, dynamic light scattering, and zeta potential analysis ( ≈ − 33 mV). The in vivo biological effects of Zn₃(PO₄)₂ nanoparticles were evaluated in a murine model, with particular emphasis on endocrine function alongside hepatic and renal parameters. Serum biomarkers of liver function (ALT, AST, and ALP), renal function (creatinine and urea), and endocrine regulation (ACTH, cortisol, and thyroid hormones) were measured at different time intervals following nanoparticle administration and compared with control animals. Transient alterations in hepatic and renal biomarkers, as well as adrenal hormone levels, were observed after 10 days of treatment, while prolonged exposure did not result in sustained or progressive changes. The effects on thyroid hormone levels appeared limited under the studied conditions. Overall, these findings suggest that low-temperature synthesized zinc phosphate nanoparticles induced mainly transient and adaptive physiological responses under the studied conditions, without evidence of sustained or progressive hepatic, renal, or endocrine disruption. However, further mechanistic and tissue-level studies are required before definitive conclusions regarding long-term safety can be made.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Endocrine and Metabolic Effects of Zinc Phosphate Nanoparticles In vivo Following Treatment with Low-Temperature Synthesis and Comprehensive Physicochemical Characterization

  • 期刊论文

  • 发表日期：

    2026年7月22日

查看全文
  • Ebtesam Al-Suhaimi,
  • Muhammad Nawaz,
  • Hussain Abdullah Alhawaj,
  • Noha Bin Mahfoz,
  • Joud Albaqqal,
  • Fatimah Al-Shabaan,
  • Raseel Al-Sunbul,
  • Leen Al-kuwaykibi,
  • Meneerah. A. Aljafary,
  • Adeeb Shehzad,
  • A. H. Homieda

摘要

Nanotechnology has emerged as a rapidly expanding field with broad applications across biomedical, environmental, and industrial sectors. Among nanomaterials, zinc phosphate nanoparticles have gained increasing attention due to their biocompatibility, biosafety, low toxicity, and environmental compatibility. In the present study, zinc phosphate nanoparticles (Zn₃(PO₄)₂ NPs) were chemically synthesized using a low-temperature method, followed by comprehensive physicochemical characterization. The morphology and nanoscale dimensions (~ 43 nm) of the dehydrated nanoparticles were examined using transmission electron microscopy, while elemental composition, crystallinity, surface charge, and dispersion behavior were assessed using EDX, XRD, dynamic light scattering, and zeta potential analysis ( ≈ − 33 mV). The in vivo biological effects of Zn₃(PO₄)₂ nanoparticles were evaluated in a murine model, with particular emphasis on endocrine function alongside hepatic and renal parameters. Serum biomarkers of liver function (ALT, AST, and ALP), renal function (creatinine and urea), and endocrine regulation (ACTH, cortisol, and thyroid hormones) were measured at different time intervals following nanoparticle administration and compared with control animals. Transient alterations in hepatic and renal biomarkers, as well as adrenal hormone levels, were observed after 10 days of treatment, while prolonged exposure did not result in sustained or progressive changes. The effects on thyroid hormone levels appeared limited under the studied conditions. Overall, these findings suggest that low-temperature synthesized zinc phosphate nanoparticles induced mainly transient and adaptive physiological responses under the studied conditions, without evidence of sustained or progressive hepatic, renal, or endocrine disruption. However, further mechanistic and tissue-level studies are required before definitive conclusions regarding long-term safety can be made.