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<p>Engineering nanocarriers to overcome the disadvantages of traditional chemotherapy and integrate cooperative theranostic modes remains challenging. Herein, a versatile nanocarrier capable of photothermal/pH responsivity was facilely engineered with cyclodextrin-based metal-organic framework (CD-MOF)&#xa0;and polydopamine (PDA) coating&#xa0;for the effective co-delivery of resveratrol (RES) and doxorubicin (DOX) and chemo-photothermal synergistic effects. The MOF&#xa0;core prepared under alkaline conditions efficiently loads hydrophobic RES (10.2%), enhancing its solubility and stability. PDA coating, which is also engineered under alkaline conditions, facilitates DOX adsorption and confers photothermal responsiveness under near-infrared irradiation (NIR), with a photothermal conversion efficiency of 29.3%. Upon laser exposure, localized hyperthermia promotes drug release and cellular uptake. In the acidic tumor microenvironment, the nanocarrier disassembles to release RES, which synergistically promotes DOX efficacy&#xa0;and enhances cytotoxicity (cell viability &lt; 20% at 10&#xa0;µg mL<sup>− 1</sup>). The results&#xa0;demonstrate that the developed nanocarriers exhibit high drug-loading capacity, excellent biocompatibility, and potent antitumor activity through combined chemo-photothermal therapy. This work&#xa0;proposes&#xa0;a promising strategy for engineering multifunctional nanocarriers and provides an effective multi-modal nanoplatform for cancer treatment.</p>

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Fabrication and Evaluation of pH/Photothermal Responsive Nanocarriers with Cyclodextrin-based Metal-Organic Framework for Co-delivery of Resveratrol and Doxorubicin for Synergistic Tumor Therapy

  • 期刊论文

  • 发表日期：

    2026年6月25日

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  • Xuanxuan Gao,
  • Ruihong Lv,
  • Rumeng Tian,
  • Yanhui Yu,
  • Wenjuan Fang,
  • Yumeng Yan,
  • Yaqi Duan,
  • Hui Gao,
  • Huiru Shen,
  • Jing Guo,
  • Yanting Liu,
  • Yongsheng Ji

摘要

Engineering nanocarriers to overcome the disadvantages of traditional chemotherapy and integrate cooperative theranostic modes remains challenging. Herein, a versatile nanocarrier capable of photothermal/pH responsivity was facilely engineered with cyclodextrin-based metal-organic framework (CD-MOF) and polydopamine (PDA) coating for the effective co-delivery of resveratrol (RES) and doxorubicin (DOX) and chemo-photothermal synergistic effects. The MOF core prepared under alkaline conditions efficiently loads hydrophobic RES (10.2%), enhancing its solubility and stability. PDA coating, which is also engineered under alkaline conditions, facilitates DOX adsorption and confers photothermal responsiveness under near-infrared irradiation (NIR), with a photothermal conversion efficiency of 29.3%. Upon laser exposure, localized hyperthermia promotes drug release and cellular uptake. In the acidic tumor microenvironment, the nanocarrier disassembles to release RES, which synergistically promotes DOX efficacy and enhances cytotoxicity (cell viability < 20% at 10 µg mL− 1). The results demonstrate that the developed nanocarriers exhibit high drug-loading capacity, excellent biocompatibility, and potent antitumor activity through combined chemo-photothermal therapy. This work proposes a promising strategy for engineering multifunctional nanocarriers and provides an effective multi-modal nanoplatform for cancer treatment.