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<p>Ocular surface conjunctivitis is a prevalent inflammatory ocular disease, yet current topical formulations are limited by low bioavailability, poor targeting, and inadequate stability of active ingredients. Here, we developed a pH-responsive drug-loaded hydrogel composed of phenylboronic acid-grafted chitosan (CS-PBA) and β-cyclodextrin-curcumin (β-CD/Cur) inclusion complexes, characterized its structure and physicochemical properties, and systematically evaluated its therapeutic functions. The hydrogel formed rapidly at room temperature via boronate ester bonds, displaying an interconnected porous network and pH-responsive swelling in acidic inflammatory microenvironments. It achieved high drug encapsulation efficiency and sustained curcumin release for up to 48&#xa0;h. In vitro results demonstrated good biocompatibility, effective antibacterial activity, and obvious immunomodulatory effect by inhibiting M1 macrophage polarization while promoting M2 polarization. This multifunctional hydrogel offers a promising platform for precise topical treatment of conjunctivitis, with notable clinical translation potential.</p>

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Immunomodulatory Phenylboronic Acid-Chitosan Hydrogel Integrated with β-CD/Curcumin for Targeted Conjunctivitis Therapy

  • 期刊论文

  • 发表日期：

    2026年6月15日

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  • Zifeng Deng,
  • Xilang Wang

摘要

Ocular surface conjunctivitis is a prevalent inflammatory ocular disease, yet current topical formulations are limited by low bioavailability, poor targeting, and inadequate stability of active ingredients. Here, we developed a pH-responsive drug-loaded hydrogel composed of phenylboronic acid-grafted chitosan (CS-PBA) and β-cyclodextrin-curcumin (β-CD/Cur) inclusion complexes, characterized its structure and physicochemical properties, and systematically evaluated its therapeutic functions. The hydrogel formed rapidly at room temperature via boronate ester bonds, displaying an interconnected porous network and pH-responsive swelling in acidic inflammatory microenvironments. It achieved high drug encapsulation efficiency and sustained curcumin release for up to 48 h. In vitro results demonstrated good biocompatibility, effective antibacterial activity, and obvious immunomodulatory effect by inhibiting M1 macrophage polarization while promoting M2 polarization. This multifunctional hydrogel offers a promising platform for precise topical treatment of conjunctivitis, with notable clinical translation potential.