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<p>The present study reports the development and optimization of ciprofloxacin–curcumin–silver–loaded gelatin hydrogel films (CCHF) intended for wound healing and infection control. A Box–Behnken Design was applied to study the effect of gelatin concentration, curcumin loading, and ciprofloxacin–silver content on swelling behavior, drug loading efficiency, and cumulative drug release at 12&#xa0;h. Seventeen formulations were prepared, among which CCHF3 was identified as the optimized formulation, showing optimal swelling (409 ± 12%), high drug loading (81.4 ± 2.0%), and sustained drug release (88.3 ± 1.7%). FTIR and ¹H NMR analyses confirmed successful complexation of ciprofloxacin with silver and compatibility among formulation components. The optimized film exhibited good mechanical flexibility, uniform thickness, and high equilibrium water content, indicating favorable physicochemical stability. Antioxidant studies revealed strong DPPH and NBT radical scavenging activity, while antibacterial evaluation demonstrated enhanced inhibition against <i>Staphylococcus aureus</i> and <i>Escherichia coli</i>. The synergistic incorporation of ciprofloxacin, curcumin, and silver within a gelatin matrix provides a multifunctional, biocompatible platform with promising potential for topical wound management and localized infection control.</p>

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Response Surface Optimization of Ciprofloxacin–Curcumin Hydrogel Film for Enhanced Wound Healing

  • 期刊论文

  • 发表日期：

    2026年6月25日

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  • Manoj Kumar Mishra,
  • Kantrol Kumar Sahu,
  • Wasim Akram

摘要

The present study reports the development and optimization of ciprofloxacin–curcumin–silver–loaded gelatin hydrogel films (CCHF) intended for wound healing and infection control. A Box–Behnken Design was applied to study the effect of gelatin concentration, curcumin loading, and ciprofloxacin–silver content on swelling behavior, drug loading efficiency, and cumulative drug release at 12 h. Seventeen formulations were prepared, among which CCHF3 was identified as the optimized formulation, showing optimal swelling (409 ± 12%), high drug loading (81.4 ± 2.0%), and sustained drug release (88.3 ± 1.7%). FTIR and ¹H NMR analyses confirmed successful complexation of ciprofloxacin with silver and compatibility among formulation components. The optimized film exhibited good mechanical flexibility, uniform thickness, and high equilibrium water content, indicating favorable physicochemical stability. Antioxidant studies revealed strong DPPH and NBT radical scavenging activity, while antibacterial evaluation demonstrated enhanced inhibition against Staphylococcus aureus and Escherichia coli. The synergistic incorporation of ciprofloxacin, curcumin, and silver within a gelatin matrix provides a multifunctional, biocompatible platform with promising potential for topical wound management and localized infection control.