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<p>Colorectal cancer remains a major health challenge, necessitating the development of effective and biocompatible nanomaterials for therapeutic applications. Polymer coating of nanoparticles can enhance stability, prevent aggregation, and improve interaction with cancer cells. In this study, sodium alginate coated Ta₂O₅ (Ta₂O₅-SA) nanoparticles were synthesized and characterized. X-ray diffraction revealed a reduction in crystallite size from 27&#xa0;nm (Ta₂O₅) to 22&#xa0;nm (Ta₂O₅-SA), while TEM and DLS confirmed spherical, well-dispersed nanoparticles with decreased hydrodynamic size (114.8&#xa0;nm vs. 143.6&#xa0;nm). UV–Vis spectroscopy showed a slight increase in band gap (4.48 → 4.60&#xa0;eV), and PL spectra displayed multiple emission peaks, reflecting surface and defect-related states. Ta₂O₅-SA exhibited superior anticancer activity against HCT-116 colon cancer cells (IC₅₀ 7.1&#xa0;µg/mL vs. 9.5&#xa0;µg/mL) with apoptotic morphological changes, as well as enhanced antibacterial and antioxidant activities. Ta₂O₅-SA nanoparticles exhibited excellent biocompatibility against L929 fibroblast cells, with cell viability above 82%, indicating their safety for biomedical applications. The improved performance is attributed to polymer-assisted stabilization, reduced particle size, and increased surface reactivity, highlighting Ta₂O₅-SA as a promising multifunctional nanocomposite for cancer therapy and biomedical applications.</p>

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Polymer Based Sodium Alginate-Stabilized Ta₂O₅ Nanoparticles with Enhanced Antibacterial, Anticancer, and Antioxidant Activities

  • 期刊论文

  • 发表日期：

    2026年7月2日

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  • Anoop Dev,
  • Sarita Chaudhary,
  • Sidhant Das,
  • Vishal Sandhwar,
  • Diksha Aggarwal,
  • Soumya V Menon,
  • Indumathi Thangavelu,
  • Srinivas Tadepalli

摘要

Colorectal cancer remains a major health challenge, necessitating the development of effective and biocompatible nanomaterials for therapeutic applications. Polymer coating of nanoparticles can enhance stability, prevent aggregation, and improve interaction with cancer cells. In this study, sodium alginate coated Ta₂O₅ (Ta₂O₅-SA) nanoparticles were synthesized and characterized. X-ray diffraction revealed a reduction in crystallite size from 27 nm (Ta₂O₅) to 22 nm (Ta₂O₅-SA), while TEM and DLS confirmed spherical, well-dispersed nanoparticles with decreased hydrodynamic size (114.8 nm vs. 143.6 nm). UV–Vis spectroscopy showed a slight increase in band gap (4.48 → 4.60 eV), and PL spectra displayed multiple emission peaks, reflecting surface and defect-related states. Ta₂O₅-SA exhibited superior anticancer activity against HCT-116 colon cancer cells (IC₅₀ 7.1 µg/mL vs. 9.5 µg/mL) with apoptotic morphological changes, as well as enhanced antibacterial and antioxidant activities. Ta₂O₅-SA nanoparticles exhibited excellent biocompatibility against L929 fibroblast cells, with cell viability above 82%, indicating their safety for biomedical applications. The improved performance is attributed to polymer-assisted stabilization, reduced particle size, and increased surface reactivity, highlighting Ta₂O₅-SA as a promising multifunctional nanocomposite for cancer therapy and biomedical applications.