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<p>The development of implantable thermo-responsive magnetic nanofibers loaded with silibinin offers a promising strategy for the localized treatment of melanoma. This approach integrates precise site-specific drug delivery with controllable heat generation to enhance hyperthermia-assisted chemotherapy. In this study, multifunctional thermo-responsive copolymer (PNIPAAm-b-PLLA(PNLA)) were fabricated via electrospinning, incorporating magnetic nanoparticles together with silibinin, a natural anticancer compound. The resulting nanofibers were engineered to respond simultaneously to temperature variations and external magnetic fields, enabling finely tunable physicochemical properties and functional behavior. When exposed to an AMF, the fibers generated heat in a reversible ON–OFF manner, inducing localized thermal stimulation. This heat triggered reversible structural changes within the nanofibers, allowing accurate, repeatable, and on-demand release of silibinin.<i> In vitro </i>experiments demonstrated that applying the AMF for only 5&#xa0;min on the second and third days of incubation reduced A375 melanoma cell viability by approximately 20%, highlighting a strong synergistic effect between magnetic hyperthermia and controlled drug release. The hierarchical architecture of the nanofibers, spanning macro- to nanoscale features, supports efficient heat generation and tightly regulated drug delivery. Overall, this thermo-responsive magnetic nanofiber platform effectively combines thermal therapy and chemotherapy, presenting a powerful and targeted approach for localized melanoma treatment.</p> Graphical Abstract <p></p>

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Heat-triggered Magnetic Nanofibers Enabling Precision Silibinin Release and Superior Melanoma Cell Killing

  • 期刊论文

  • 发表日期：

    2026年7月10日

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  • Akram Firouzi Amandi,
  • Tohid Kazemi,
  • Mehdi Dadashpour,
  • Bahman Yousefi

摘要

The development of implantable thermo-responsive magnetic nanofibers loaded with silibinin offers a promising strategy for the localized treatment of melanoma. This approach integrates precise site-specific drug delivery with controllable heat generation to enhance hyperthermia-assisted chemotherapy. In this study, multifunctional thermo-responsive copolymer (PNIPAAm-b-PLLA(PNLA)) were fabricated via electrospinning, incorporating magnetic nanoparticles together with silibinin, a natural anticancer compound. The resulting nanofibers were engineered to respond simultaneously to temperature variations and external magnetic fields, enabling finely tunable physicochemical properties and functional behavior. When exposed to an AMF, the fibers generated heat in a reversible ON–OFF manner, inducing localized thermal stimulation. This heat triggered reversible structural changes within the nanofibers, allowing accurate, repeatable, and on-demand release of silibinin. In vitro experiments demonstrated that applying the AMF for only 5 min on the second and third days of incubation reduced A375 melanoma cell viability by approximately 20%, highlighting a strong synergistic effect between magnetic hyperthermia and controlled drug release. The hierarchical architecture of the nanofibers, spanning macro- to nanoscale features, supports efficient heat generation and tightly regulated drug delivery. Overall, this thermo-responsive magnetic nanofiber platform effectively combines thermal therapy and chemotherapy, presenting a powerful and targeted approach for localized melanoma treatment.

Graphical Abstract