Scholarlink

<p>Dacarbazine (DTIC) is an alkylating chemotherapeutic agent with demonstrated anti-tumor activity but limited utility for intracranial applications due to its chemical instability, short systemic half-life, and inability to cross the blood-brain barrier. Strategies that stabilize DTIC in the solid form for localized delivery therefore are of significant interest due to the material challenges. In this study, nanofibers with various polyvinyl alcohol (PVA)-to-dacarbazine ratios ranging from 2.5:1, 5:1, 7.5:1, to 10:1 were developed using alternating-current electrospinning (ACES) at an extremely high production rate. Their structural and physiochemical properties were systematically characterized to assess the feasibility of this approach using different characterization methods such as X-ray diffraction (XRD), Fourier-transform infrared (FT-IR) spectroscopy, differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Additionally, the encapsulation efficiency (EE) and the drug release profile was evaluated using Ultraviolet-visible spectroscopy (UV-Vis). The characterization results show that nanofibers obtained using the ACES approach have good DTIC dispersion in the PVA matrix and the DTIC remains individualistic in the nanofiber. These results collectively demonstrate that ACES enables the incorporation of dacarbazine into PVA nanofibers while preserving favorable fiber morphology and promoting solid-state stabilization. This work shows the novelty in the application of ACES to fabricate dacarbazine-loaded PVA nanofibers with controlled morphology and solid-state drug stabilization. It also establishes a foundational materials platform for localized dacarbazine delivery and providing a basis for future studies focused on drug release behavior, stability, and therapeutic application.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Innovative AC Electrospinning and Characterization of Nanofibers Comprised of Polyvinyl Alcohol and Dacarbazine for Solid State Drug Delivery of Cancer Therapeutic

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月30日

查看全文
  • Rachel E. Murphy,
  • Yongzhe Yan,
  • Jadyn Parker,
  • Subhayu Sen,
  • W. Anthony Brayer,
  • Haibin Ning

摘要

Dacarbazine (DTIC) is an alkylating chemotherapeutic agent with demonstrated anti-tumor activity but limited utility for intracranial applications due to its chemical instability, short systemic half-life, and inability to cross the blood-brain barrier. Strategies that stabilize DTIC in the solid form for localized delivery therefore are of significant interest due to the material challenges. In this study, nanofibers with various polyvinyl alcohol (PVA)-to-dacarbazine ratios ranging from 2.5:1, 5:1, 7.5:1, to 10:1 were developed using alternating-current electrospinning (ACES) at an extremely high production rate. Their structural and physiochemical properties were systematically characterized to assess the feasibility of this approach using different characterization methods such as X-ray diffraction (XRD), Fourier-transform infrared (FT-IR) spectroscopy, differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Additionally, the encapsulation efficiency (EE) and the drug release profile was evaluated using Ultraviolet-visible spectroscopy (UV-Vis). The characterization results show that nanofibers obtained using the ACES approach have good DTIC dispersion in the PVA matrix and the DTIC remains individualistic in the nanofiber. These results collectively demonstrate that ACES enables the incorporation of dacarbazine into PVA nanofibers while preserving favorable fiber morphology and promoting solid-state stabilization. This work shows the novelty in the application of ACES to fabricate dacarbazine-loaded PVA nanofibers with controlled morphology and solid-state drug stabilization. It also establishes a foundational materials platform for localized dacarbazine delivery and providing a basis for future studies focused on drug release behavior, stability, and therapeutic application.