Scholarlink

<p>In the present study, the key problem addressed is the limited biocompatibility, toxicity and lack of multifunctionality in conventional nanoparticles based therapeutic system, which necessitates the development of safer, sustainable, and functionally enhanced alternatives. A green synthesis method utilizing <i>Dictyota bartayresiana</i> (macroalgae) extract and zinc acetate were used to produce zinc oxide nanoparticles. Glutaraldehyde was used as a cross-linker to integrate the green synthesised nanoparticles into mannanoligosaccharide (MOS), a naturally occurring prebiotics biopolymer. Glutaraldehyde was utilized as a crosslinking agent to form covalent linkages among MOS and ZNPs, enhancing structural stability, dispersion, and biological activity compared to simple physical mixtures. The synthesized zinc nanoparticles (ZNPs) and MOS-ZNPs crosslinked with glutaraldehyde have been independently characterized the usage of UV-Vis spectroscopy, FTIR, XRD, TGA, and SEM with EDX analyses. The antioxidant activity has been assessed the usage of the DPPH (2, 2-diphenyl-1-picrylhydrazyl) assay of (56.8% at 500&#xa0;µg/mL). The integration of MOS with zinc nanoparticles showed remarkable antimicrobial activities against pathogenic bacteria and fungi, the MIC values was found to be MIC values (125–250&#xa0;µg/mL) and (125–500&#xa0;µg/mL), respectively, suggesting its potential as a multifunctional bioactive material. The anticancer effect of the substance was evaluated through MTT assay testing and apoptosis examination at the A549 lung cancer cell line. The IC50 value of 20.64&#xa0;µg/mL showed strong cytotoxic effects which caused cell death through apoptosis. Overall, the incorporation of zinc nanoparticles greatly enhanced the stability and biocompatibility of mannanoligosaccharides. These results show that the MOS-ZNPs composite has great potential, offering prebiotic benefits along with antimicrobial and anticancer properties, making it a valuable option for biomedical and therapeutic applications.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Green Synthesized MOS-Zinc Oxide Nanoparticles from Dictyota bartayresiana Extract with Enhanced Antioxidant, Antimicrobial, and Anticancer Efficacy

  • 期刊论文

  • 发表日期：

    2026年5月26日

查看全文
  • Gurunathan Baskar,
  • Vadivel Kalkieshwari,
  • Christian David Paul Bernita Celas,
  • Muthusamy Muthulakshmi

摘要

In the present study, the key problem addressed is the limited biocompatibility, toxicity and lack of multifunctionality in conventional nanoparticles based therapeutic system, which necessitates the development of safer, sustainable, and functionally enhanced alternatives. A green synthesis method utilizing Dictyota bartayresiana (macroalgae) extract and zinc acetate were used to produce zinc oxide nanoparticles. Glutaraldehyde was used as a cross-linker to integrate the green synthesised nanoparticles into mannanoligosaccharide (MOS), a naturally occurring prebiotics biopolymer. Glutaraldehyde was utilized as a crosslinking agent to form covalent linkages among MOS and ZNPs, enhancing structural stability, dispersion, and biological activity compared to simple physical mixtures. The synthesized zinc nanoparticles (ZNPs) and MOS-ZNPs crosslinked with glutaraldehyde have been independently characterized the usage of UV-Vis spectroscopy, FTIR, XRD, TGA, and SEM with EDX analyses. The antioxidant activity has been assessed the usage of the DPPH (2, 2-diphenyl-1-picrylhydrazyl) assay of (56.8% at 500 µg/mL). The integration of MOS with zinc nanoparticles showed remarkable antimicrobial activities against pathogenic bacteria and fungi, the MIC values was found to be MIC values (125–250 µg/mL) and (125–500 µg/mL), respectively, suggesting its potential as a multifunctional bioactive material. The anticancer effect of the substance was evaluated through MTT assay testing and apoptosis examination at the A549 lung cancer cell line. The IC50 value of 20.64 µg/mL showed strong cytotoxic effects which caused cell death through apoptosis. Overall, the incorporation of zinc nanoparticles greatly enhanced the stability and biocompatibility of mannanoligosaccharides. These results show that the MOS-ZNPs composite has great potential, offering prebiotic benefits along with antimicrobial and anticancer properties, making it a valuable option for biomedical and therapeutic applications.