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<p>To increase the biomedical potential of CaCO<sub>3</sub>, Er³⁺and Dy³⁺were doped in CaCO<sub>3</sub>/PEG nanocomposites through biomimetic synthesis using dolomite rock as a natural carbonate source. The optical, functional, structural, elemental, and morphological properties of the produced nanocomposites were thoroughly examined. The UV-Vis DRS and PL spectra showed a blue shift and a band gap of 3.0–2.43&#xa0;eV as the dopant concentration increased, along with absorption between 257 and 319&#xa0;nm and emission within 454 –448&#xa0;nm. The crystalline calcite phase with particle sizes ranging from 30 to 36&#xa0;nm was confirmed by XRD and HRTEM analyses, and the successful incorporation of Er<sup>3+</sup> and Dy<sup>3+</sup> ions was confirmed by FTIR and XPS investigations.Uniform spherical nanoparticles were visible in FESEM images, and EDX verified elemental purity. Compared to samples doped with Er<sup>3+</sup> (16 and 11&#xa0;mm), samples doped with Dy<sup>3+</sup> exhibited larger inhibition zones for antibacterial activity against <i>Staphylococcus aureus</i> and <i>Salmonella sp.</i> (18 and 12&#xa0;mm). IC<sub>50</sub> values of 89.27&#xa0;µg/mL (Dy<sup>3+</sup>) and 139.25&#xa0;µg/mL (Er<sup>3+</sup>) for in vitro MTT assays against <i>MCF-7</i> breast cancer cells demonstrated concentration-dependent cytotoxicity, confirming strong anticancer efficacy and good biocompatibility. These results imply that Dy<sup>3+</sup>-doped CaCO<sub>3</sub>/PEG nanocomposites are excellent antibacterial and anticancer agents, making them attractive options for biomedical applications.</p>

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Synergistic Cytotoxic and Antibacterial Effects of Erbium (Er3+) and Dysprosium (Dy3+) Doped CaCO3/PEG Nanocomposites

  • 期刊论文

  • 发表日期：

    2026年5月28日

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  • E. Thenpandiyan,
  • G. Suresh,
  • T. Sathishpriya,
  • S. Senthil,
  • K. Dhanaraj,
  • N. Prathap,
  • V. Ramasamy

摘要

To increase the biomedical potential of CaCO3, Er³⁺and Dy³⁺were doped in CaCO3/PEG nanocomposites through biomimetic synthesis using dolomite rock as a natural carbonate source. The optical, functional, structural, elemental, and morphological properties of the produced nanocomposites were thoroughly examined. The UV-Vis DRS and PL spectra showed a blue shift and a band gap of 3.0–2.43 eV as the dopant concentration increased, along with absorption between 257 and 319 nm and emission within 454 –448 nm. The crystalline calcite phase with particle sizes ranging from 30 to 36 nm was confirmed by XRD and HRTEM analyses, and the successful incorporation of Er3+ and Dy3+ ions was confirmed by FTIR and XPS investigations.Uniform spherical nanoparticles were visible in FESEM images, and EDX verified elemental purity. Compared to samples doped with Er3+ (16 and 11 mm), samples doped with Dy3+ exhibited larger inhibition zones for antibacterial activity against Staphylococcus aureus and Salmonella sp. (18 and 12 mm). IC50 values of 89.27 µg/mL (Dy3+) and 139.25 µg/mL (Er3+) for in vitro MTT assays against MCF-7 breast cancer cells demonstrated concentration-dependent cytotoxicity, confirming strong anticancer efficacy and good biocompatibility. These results imply that Dy3+-doped CaCO3/PEG nanocomposites are excellent antibacterial and anticancer agents, making them attractive options for biomedical applications.