Scholarlink

<p>Conventional paraffin-gauze dressings are passive wound contact layers, entirely devoid of therapeutic agents. In clinical practice, a separate topical antimicrobial ointment must be applied alongside the dressing, adding procedural steps and dosing variability. This study aimed to transform this passive, single-function dressing into an active, dual-function system: one that simultaneously provides non-adherent wound protection and delivers drug therapy directly to the wound bed, eliminating the need for a separately applied ointment. Mupirocin-loaded Nanostructured Lipid Carriers (Mup-NLC) were incorporated for sustained, controlled antimicrobial delivery, addressing mupirocin’s poor aqueous solubility and rapid wound-site clearance. Curcumin was dispersed as a free drug in the paraffin base, exploiting its lipophilic compatibility to provide anti-inflammatory and wound-healing activity through direct wound contact. Mup-NLC were formulated by modified emulsion–solvent evaporation and characterized for particle size, PDI, zeta potential, entrapment efficiency, drug loading, FTIR, DSC, and FE-SEM. The optimized formulation (F8: GMS: oleic acid 70:30) achieved particle size 166.6&#xa0;nm, PDI 0.194, zeta potential − 36.6 mV, entrapment efficiency 65.25%, and drug loading 26.75%. Incorporation into the paraffin matrix shifted mupirocin release from Fickian diffusion (Korsmeyer-Peppas R²=0.9681, <i>n</i> = 0.2131) to near zero-order kinetics (R²=0.8685), ensuring constant therapeutic flux. In an excision wound model in Wistar albino rats, the Mup-NLC+Curc-Paraffin dressing achieved 100% wound contraction by Day 21, surpassing the positive control (97.89%), Mup-NLC alone (98.95%), and Curc-Paraffin (98.87%). Histopathology confirmed superior re-epithelialization, organized collagen deposition, and angiogenesis. This dual-function platform consolidates wound protection and controlled drug delivery into a single, ready-to-apply product, advancing beyond the conventional dual-product approach.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Transforming Passive Wound Dressings into Active Delivery Systems: A Dual-Functionalized NLC-Paraffin Matrix for Accelerated Tissue Repair

  • 期刊论文

  • 发表日期：

    2026年5月21日

查看全文
  • Keya Nath,
  • Tapash Chakraborty,
  • Swapnanil Mahanta,
  • Kristipriya Boruah

摘要

Conventional paraffin-gauze dressings are passive wound contact layers, entirely devoid of therapeutic agents. In clinical practice, a separate topical antimicrobial ointment must be applied alongside the dressing, adding procedural steps and dosing variability. This study aimed to transform this passive, single-function dressing into an active, dual-function system: one that simultaneously provides non-adherent wound protection and delivers drug therapy directly to the wound bed, eliminating the need for a separately applied ointment. Mupirocin-loaded Nanostructured Lipid Carriers (Mup-NLC) were incorporated for sustained, controlled antimicrobial delivery, addressing mupirocin’s poor aqueous solubility and rapid wound-site clearance. Curcumin was dispersed as a free drug in the paraffin base, exploiting its lipophilic compatibility to provide anti-inflammatory and wound-healing activity through direct wound contact. Mup-NLC were formulated by modified emulsion–solvent evaporation and characterized for particle size, PDI, zeta potential, entrapment efficiency, drug loading, FTIR, DSC, and FE-SEM. The optimized formulation (F8: GMS: oleic acid 70:30) achieved particle size 166.6 nm, PDI 0.194, zeta potential − 36.6 mV, entrapment efficiency 65.25%, and drug loading 26.75%. Incorporation into the paraffin matrix shifted mupirocin release from Fickian diffusion (Korsmeyer-Peppas R²=0.9681, n = 0.2131) to near zero-order kinetics (R²=0.8685), ensuring constant therapeutic flux. In an excision wound model in Wistar albino rats, the Mup-NLC+Curc-Paraffin dressing achieved 100% wound contraction by Day 21, surpassing the positive control (97.89%), Mup-NLC alone (98.95%), and Curc-Paraffin (98.87%). Histopathology confirmed superior re-epithelialization, organized collagen deposition, and angiogenesis. This dual-function platform consolidates wound protection and controlled drug delivery into a single, ready-to-apply product, advancing beyond the conventional dual-product approach.