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<p>Oral squamous cell carcinoma, a leading form of solid tumor, often presents with poor prognosis and systemic toxicity due to the nonspecific nature of the chemotherapy. The present investigation describes a QbD-based approach to synthesize Gold-silver bimetallic nanoparticles (Au@Ag-BMNPs) as a chemo-free photothermal therapeutic modality for tumor ablation. A one-pot synthesis approach using fucoidan as a reducing and stabilizing agent was achieved using factorial and central composite designs for systematic optimization of Au@Ag-BMNPs. The developed Au@Ag-BMNPs exhibited nanoscale size, effective cellular uptake, and photothermal conversion activity upon irradiation with NIR light. In vitro studies suggested enhanced activity of the Au@Ag-BMNPs when coupled with NIR laser irradiation compared to Au@Ag-BMNPs alone, indicating hyperthermia-induced apoptotic events and ROS generation, which was confirmed by the expression of PTEN, Caspase 3, HSPA1A mRNAs, and HSP70, Caspase 9 proteins. Hemocompatibility studies, as a bridging investigation between formulation and in vivo scalability, yielded encouraging results. This study hereby establishes a solid proof-of-concept for the QbD-optimized, laser-guided, drug-free anticancer potential of Au@Ag-BMNPs for oral cancer, with possible application to other solid tumors.</p> Graphical Abstract <p></p>

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Investigating Fucoidan-Cored Gold@Silver Bimetallic Nanoparticles for Plasmon-Guided Thermal Ablation and ROS Synergy in Cancer Therapy

  • 期刊论文

  • 发表日期：

    2026年5月20日

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  • Tanisha Gupta,
  • Nupur Vasdev,
  • Pravin Kamble,
  • Shubham Ramdas Mule,
  • Anuja Muley,
  • Rakesh Kumar Tekade

摘要

Oral squamous cell carcinoma, a leading form of solid tumor, often presents with poor prognosis and systemic toxicity due to the nonspecific nature of the chemotherapy. The present investigation describes a QbD-based approach to synthesize Gold-silver bimetallic nanoparticles (Au@Ag-BMNPs) as a chemo-free photothermal therapeutic modality for tumor ablation. A one-pot synthesis approach using fucoidan as a reducing and stabilizing agent was achieved using factorial and central composite designs for systematic optimization of Au@Ag-BMNPs. The developed Au@Ag-BMNPs exhibited nanoscale size, effective cellular uptake, and photothermal conversion activity upon irradiation with NIR light. In vitro studies suggested enhanced activity of the Au@Ag-BMNPs when coupled with NIR laser irradiation compared to Au@Ag-BMNPs alone, indicating hyperthermia-induced apoptotic events and ROS generation, which was confirmed by the expression of PTEN, Caspase 3, HSPA1A mRNAs, and HSP70, Caspase 9 proteins. Hemocompatibility studies, as a bridging investigation between formulation and in vivo scalability, yielded encouraging results. This study hereby establishes a solid proof-of-concept for the QbD-optimized, laser-guided, drug-free anticancer potential of Au@Ag-BMNPs for oral cancer, with possible application to other solid tumors.

Graphical Abstract