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<p>Iron oxide based magnetic nanoparticles have been explored extensively for applications in cancer treatments such as magnetic hyperthermia, targeted drug delivery and magnetic resonance imaging. These nanoparticles exhibit exquisite properties in laboratories while decline/reduction in efficacy is observed when interacted with biological entities such as cells, blood etc. To further the application, it is necessary to study the cyto, hemo- and bio-compatibility of such nanoparticles. In this attempt, monodispersed polyethylene glycol coated cubic iron oxide nanoparticles with average edge length of about 13.7 ± 3.46&#xa0;nm have been synthesized by one step hydrothermal method. The nanoparticles show highest magnetization of 65 emu/g and negligible coercivity (⁓17 Oe) at room temperature. Potential of these PEGylated nanoparticles is explored with induction heating studies as function of applied field and nanoparticles’ concentration. At physiological safe range, these nanoparticles exhibit specific absorption rate of 101&#xa0;W/g with highest temperature rise up to 52.2 ℃ at minimum of 2&#xa0;mg/mL concentration. The cyto-, hemo- compatibility of these nanoparticles is evaluated and found that particles are compatible to normal cells. CAM assays demonstrated angiogenesis and vascularization, with an intact endothelial cell lining, indicating vascular integrity. MTT assays indicated varying levels of cytocompatibility. This comprehensive evaluation of the hemocompatibility, biocompatibility, and cytocompatibility of MNPs, with a particular emphasis on their interactions with normal cells, provides insights crucial for their clinical applicability. Also demonstrating cytotoxicity against MCF-7 breast cancer cells, achieving up to 72.56 ± 2.1% targeted therapeutic efficiency.</p>

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In-situ Polyethylene Glycol Functionalized Iron Oxide Nanoparticles for Biomedical Magnetic Hyperthermia Application

  • 期刊论文

  • 发表日期：

    2026年5月15日

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  • Pooja R. Patil,
  • Sagar A. Patil,
  • Pooja P. Kolekar,
  • Vishwajeet M. Khot,
  • Meghnad G. Joshi,
  • Krishnan Mayakannan

摘要

Iron oxide based magnetic nanoparticles have been explored extensively for applications in cancer treatments such as magnetic hyperthermia, targeted drug delivery and magnetic resonance imaging. These nanoparticles exhibit exquisite properties in laboratories while decline/reduction in efficacy is observed when interacted with biological entities such as cells, blood etc. To further the application, it is necessary to study the cyto, hemo- and bio-compatibility of such nanoparticles. In this attempt, monodispersed polyethylene glycol coated cubic iron oxide nanoparticles with average edge length of about 13.7 ± 3.46 nm have been synthesized by one step hydrothermal method. The nanoparticles show highest magnetization of 65 emu/g and negligible coercivity (⁓17 Oe) at room temperature. Potential of these PEGylated nanoparticles is explored with induction heating studies as function of applied field and nanoparticles’ concentration. At physiological safe range, these nanoparticles exhibit specific absorption rate of 101 W/g with highest temperature rise up to 52.2 ℃ at minimum of 2 mg/mL concentration. The cyto-, hemo- compatibility of these nanoparticles is evaluated and found that particles are compatible to normal cells. CAM assays demonstrated angiogenesis and vascularization, with an intact endothelial cell lining, indicating vascular integrity. MTT assays indicated varying levels of cytocompatibility. This comprehensive evaluation of the hemocompatibility, biocompatibility, and cytocompatibility of MNPs, with a particular emphasis on their interactions with normal cells, provides insights crucial for their clinical applicability. Also demonstrating cytotoxicity against MCF-7 breast cancer cells, achieving up to 72.56 ± 2.1% targeted therapeutic efficiency.