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<p>Using artificial eyes for extended periods of time may cause many complications, such as constant mechanical irritation, and prolonged contact with the foreign body can trigger secondary infections. These infections are frequently challenging to treat and may require the prosthesis to be removed. Addressing these issues might involve enhancing the antimicrobial properties of the prosthesis surface, potentially reducing infection risks and improving patient comfort. We have used the Nd-YAG laser for preparing silver nanoparticles and mixing it with artificial eye components. After heat curing, the prosthesis was prepared for microbial testing against Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) in the form of cut sections and a full artificial eye using colony forming units and growth kinetic analysis. Moreover, we have studied nonlinear regression analysis procedures using the logistic and Gompertz models for describing bacterial growth rate. Our results have shown that the concentration of Ag-NPs 30% appears to be the most suitable parameter for enhancing the antimicrobial properties of the artificial eye rather than any other concentration. Furthermore, the Gompertz model proved to be the best fit, offering the most accurate representation of the growth kinetic data. This novel ocular prosthesis could be a potential candidate for application in biomedical materials.</p>

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New Antimicrobial Features of a Laser-Ablated Silver Nanoparticles Artificial Eye: Experimental Study and Theoretical Kinetic Modeling

  • 期刊论文

  • 发表日期：

    2026年5月19日

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  • Omar Abdelfattah,
  • Ahmed O. El-Gendy,
  • Khaled S. Abdelkader,
  • Esraa Ahmed,
  • Tarek Mohamed,
  • Mohamed Mobarak

摘要

Using artificial eyes for extended periods of time may cause many complications, such as constant mechanical irritation, and prolonged contact with the foreign body can trigger secondary infections. These infections are frequently challenging to treat and may require the prosthesis to be removed. Addressing these issues might involve enhancing the antimicrobial properties of the prosthesis surface, potentially reducing infection risks and improving patient comfort. We have used the Nd-YAG laser for preparing silver nanoparticles and mixing it with artificial eye components. After heat curing, the prosthesis was prepared for microbial testing against Methicillin-resistant Staphylococcus aureus (MRSA) in the form of cut sections and a full artificial eye using colony forming units and growth kinetic analysis. Moreover, we have studied nonlinear regression analysis procedures using the logistic and Gompertz models for describing bacterial growth rate. Our results have shown that the concentration of Ag-NPs 30% appears to be the most suitable parameter for enhancing the antimicrobial properties of the artificial eye rather than any other concentration. Furthermore, the Gompertz model proved to be the best fit, offering the most accurate representation of the growth kinetic data. This novel ocular prosthesis could be a potential candidate for application in biomedical materials.