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<p>The present study aimed to develop and evaluate natural gum, i.e., konjac glucomannan (KGM)-based films incorporating silver nanoparticles (AgNPs) for effective wound healing. Silver nanoparticles were synthesized using sustainable, and ecofriendly principles of green synthesis along with holistic understanding of the process using QbD principles. In this regard, the natural gum, i.e., KGM was used as both a reducing and stabilizing agent and process was microwave-assisted. Then AgNPs thus prepared exhibited particle size of 100.5 ± 10&#xa0;nm and zeta potential of -32.14 ± 2.5 mV. Then these were successfully incorporated into KGM film matrices along with tea tree oil and glycerol to enhance antimicrobial efficacy and film flexibility, respectively. The prepared films were characterized for their physical appearance, thickness (0.04 ± 0.01&#xa0;mm), folding endurance (795 ± 0.41), surface pH (6.98 ± 0.13), with moisture uptake of 13.78 ± 0.07%. while exhibiting a swelling index 151.62 ± 2.7%. Further, structural and morphological properties using FTIR, SEM-EDX, XRD, and AFM analyses were studied. Stability studies conducted under ambient, accelerated, and refrigerated conditions for 90 days revealed minimal changes in particle size, zeta potential, and UV-visible absorption, indicating good formulation stability. In vivo studies, including skin irritation assessment and wound healing evaluation using an excision wound model in rats, demonstrated that the developed AgNP-loaded KGM films were non-irritant and significantly accelerated wound contraction and epithelization compared to control groups. Histological examination further confirmed enhanced collagen deposition, re-epithelialization, and tissue regeneration in the treated groups. These findings suggest that KGM-based biopolymer films incorporating green synthesized AgNPs offer a promising multifunctional wound dressing system with effective wound healing properties for safe and sustainable wound management.</p>

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Natural Biopolymer-Based Films Containing Silver Nanoparticles for Improved Wound Healing: Green Synthesis, Optimization, and Evaluation

  • 期刊论文

  • 发表日期：

    2026年4月20日

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  • Mansi Dogra,
  • Teenu Sharma,
  • Bhupinder Singh,
  • Rajan Swami

摘要

The present study aimed to develop and evaluate natural gum, i.e., konjac glucomannan (KGM)-based films incorporating silver nanoparticles (AgNPs) for effective wound healing. Silver nanoparticles were synthesized using sustainable, and ecofriendly principles of green synthesis along with holistic understanding of the process using QbD principles. In this regard, the natural gum, i.e., KGM was used as both a reducing and stabilizing agent and process was microwave-assisted. Then AgNPs thus prepared exhibited particle size of 100.5 ± 10 nm and zeta potential of -32.14 ± 2.5 mV. Then these were successfully incorporated into KGM film matrices along with tea tree oil and glycerol to enhance antimicrobial efficacy and film flexibility, respectively. The prepared films were characterized for their physical appearance, thickness (0.04 ± 0.01 mm), folding endurance (795 ± 0.41), surface pH (6.98 ± 0.13), with moisture uptake of 13.78 ± 0.07%. while exhibiting a swelling index 151.62 ± 2.7%. Further, structural and morphological properties using FTIR, SEM-EDX, XRD, and AFM analyses were studied. Stability studies conducted under ambient, accelerated, and refrigerated conditions for 90 days revealed minimal changes in particle size, zeta potential, and UV-visible absorption, indicating good formulation stability. In vivo studies, including skin irritation assessment and wound healing evaluation using an excision wound model in rats, demonstrated that the developed AgNP-loaded KGM films were non-irritant and significantly accelerated wound contraction and epithelization compared to control groups. Histological examination further confirmed enhanced collagen deposition, re-epithelialization, and tissue regeneration in the treated groups. These findings suggest that KGM-based biopolymer films incorporating green synthesized AgNPs offer a promising multifunctional wound dressing system with effective wound healing properties for safe and sustainable wound management.