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<p>Medicinal plants have been a source of natural remedies for many conditions including infections. The ever-increasing burden of superbugs, however, demands more potent strategies. Use of silver nanoparticles (AgNPs) synthesized through plant products can provide a synergistic effect. Owing to the limited availability of cultivation area, availability of medicinal plants for pharmaceutical uses is adversely affected. Hydroponic systems can address the space constraints while providing an opportunity to be used for phytomedicinal purposes. However, the employability of hydroponically grown plants for biosynthesis of AgNPs and their pharmacodynamics effects still need to be established. The current study initiated with the optimization of the growth conditions for Basil plant in hydroponic system followed by its comparison of phytochemical content with soil-grown plants. A comparable phytochemical profile with 2.44% increased flavonoids and an 11.41% increase in tannins content was noted. The extract was used for AgNPs synthesis which was confirmed by UV-Vis analysis. FTIR, zeta-analysis and SEM-EDX analyses established the particle stability, uniform dispersity and nano-size with appropriate silver content respectively. Thereafter, in vitro testing against MDRSA through disc diffusion assay showed significant inhibition which was further strengthened by a low MIC and MBC levels of 0.156&#xa0;mg/ml and 0.625&#xa0;mg/ml respectively. These potent AgNPs were then loaded in a polymeric hydrogel and tested on a burn-induced, MDRSA skin and soft tissue infection mouse model. Total elimination of infection and speedy wound healing was observed in the hydroponically grown basil AgNPs group, thereby, establishing their antimicrobial and skin regeneration capability.</p> Graphical Abstract <p></p>

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Effective Attenuation of Multidrug Resistant Staphylococcus Aureus by Hydroponically Grown Basil Synthesized Nanoparticles in Burn Wound Model

  • 期刊论文

  • 发表日期：

    2026年4月7日

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  • Hunaiza Fatima,
  • Syed Damin Abbas Hamdani,
  • Linta Jadoon,
  • Alvina Gul,
  • Tausif Ahmed Rajput,
  • Faiza Munir,
  • Rabia Amir,
  • Mustafeez Mujtaba Babar

摘要

Medicinal plants have been a source of natural remedies for many conditions including infections. The ever-increasing burden of superbugs, however, demands more potent strategies. Use of silver nanoparticles (AgNPs) synthesized through plant products can provide a synergistic effect. Owing to the limited availability of cultivation area, availability of medicinal plants for pharmaceutical uses is adversely affected. Hydroponic systems can address the space constraints while providing an opportunity to be used for phytomedicinal purposes. However, the employability of hydroponically grown plants for biosynthesis of AgNPs and their pharmacodynamics effects still need to be established. The current study initiated with the optimization of the growth conditions for Basil plant in hydroponic system followed by its comparison of phytochemical content with soil-grown plants. A comparable phytochemical profile with 2.44% increased flavonoids and an 11.41% increase in tannins content was noted. The extract was used for AgNPs synthesis which was confirmed by UV-Vis analysis. FTIR, zeta-analysis and SEM-EDX analyses established the particle stability, uniform dispersity and nano-size with appropriate silver content respectively. Thereafter, in vitro testing against MDRSA through disc diffusion assay showed significant inhibition which was further strengthened by a low MIC and MBC levels of 0.156 mg/ml and 0.625 mg/ml respectively. These potent AgNPs were then loaded in a polymeric hydrogel and tested on a burn-induced, MDRSA skin and soft tissue infection mouse model. Total elimination of infection and speedy wound healing was observed in the hydroponically grown basil AgNPs group, thereby, establishing their antimicrobial and skin regeneration capability.

Graphical Abstract